Tohi M, Tu'akoi S, Vickers M H
Liggins Institute, University of Auckland, Auckland, New Zealand.
School of Population Health, University of Auckland, Auckland, New Zealand.
J Dev Orig Health Dis. 2023 Dec;14(6):755-762. doi: 10.1017/S2040174423000442. Epub 2024 Jan 23.
The developmental origins of health and disease (DOHaD) framework has highlighted the importance of the early life period on disease risk in later life with impacts that can span generations. A primary focus to date has been around maternal health and the 'First Thousand Days' as a key developmental window whereby an adverse environment can have lasting impacts on both mother and offspring. More recently, the impact of paternal health has gathered increasing traction as a key window for early life developmental programming. However, to date, adolescents, the next generation of parents, have attracted less attention as a key DOHaD window although many behavioural traits become entrained during adolescence and track into adulthood. This systematic review examined literature focused on identifying adolescent understanding of DOHaD concepts. Consistent across the eligible articles was that overall understanding of DOHaD-related concepts in adolescents was low. Three key themes emerged: 1. Individual-level awareness of DOHaD concepts (cognitive engagement and action of the adolescents themselves); 2. Interpersonal communication and social awareness of DOHaD concepts (cognitive engagement and communication of the DOHaD concepts to family and wider community); and 3. Health literacy and the promotion of adolescence as a key DOHaD life stage. These findings highlight the need to develop strategic approaches to increase DOHaD awareness that are not only appealing to adolescents but can also support sustained changes in health behaviour. Investment in today's adolescents has the potential to act as a NCD 'circuit breaker' and thus will yield significant dividends for future generations.
健康与疾病的发育起源（DOHaD）框架强调了生命早期阶段对晚年疾病风险的重要性，其影响可能会延续几代人。迄今为止，主要关注点一直围绕着孕产妇健康以及作为关键发育窗口的“生命最初一千天”，在这个时期，不良环境会对母亲和后代产生持久影响。最近，父亲健康的影响作为早期生命发育编程的关键窗口越来越受到关注。然而，到目前为止，作为DOHaD关键窗口的青少年（下一代父母）却较少受到关注，尽管许多行为特征在青少年时期就已形成并持续到成年。这项系统综述研究了聚焦于确定青少年对DOHaD概念理解的文献。符合条件的文章一致表明，青少年对DOHaD相关概念的总体理解程度较低。出现了三个关键主题：1. 个人层面的DOHaD概念认知（青少年自身的认知参与和行动）；2. 人际沟通和对DOHaD概念的社会认知（将DOHaD概念向家庭和更广泛社区的认知参与和传播）；3. 健康素养以及将青少年时期作为DOHaD关键生命阶段进行推广。这些发现凸显了制定战略方法以提高DOHaD认知的必要性，这些方法不仅要吸引青少年，还要支持健康行为的持续改变。对当今青少年的投资有可能成为非传染性疾病的“断路器”，从而为子孙后代带来巨大益处。
