Cifuentes Lizeth, Galbiati Francesca, Mahmud Hussain, Rometo David
Department of Medicine Division of General Internal Medicine University of Pittsburgh Medical Center Pittsburgh Pennsylvania USA.
Department of Medicine Division of Endocrinology, Diabetes, and Hypertension Brigham and Women's Hospital Harvard Medical School Boston Massachusetts USA.
Obes Sci Pract. 2023 Nov 20;10(1):e722. doi: 10.1002/osp4.722. eCollection 2024 Feb.
Very low-calorie diets (VLCDs) employing total meal replacement (TMR) offer substantial short-term weight loss. Concurrently, anti-obesity medications (AOMs) have shown promise as adjunctive treatments when combined with VLCDs.
This study aimed to investigate the impact of adjuvant AOMs on weight loss and weight regain within a comprehensive lifestyle program.
This is a retrospective study of patients with obesity enrolled in VLCD/TMR programs, specifically the OPTIFAST program.
Data from 206 patients (68% women, mean age 52.39 ± 13.05 years, BMI 41.71 ± 7.04 kg/m) were analyzed. Of these, 139 received no AOM (AOM-), while 67 received AOMs (AOM+). Total body weight loss percentages (TWL%) at 6 and 18 months were -17.87% ± 7.02 and -12.10% ± 11.56, respectively. There was no significant difference in 6-month weight loss between the AOM groups. However, the AOM + group exhibited lower weight regain (3.29 kg ± 10.19 vs. 7.61 kg ± 11.96; = 0.006) and weight regain percentage (WR%) (31.5% ± 68.7 vs. 52.16% ± 64.4; = 0.04) compared with the AOM- group.
The findings highlighted the potential of AOMs and VLCD/TMR as effective strategies for long-term weight management in individuals with obesity.
采用全餐替代(TMR)的极低热量饮食(VLCD)能实现显著的短期体重减轻。同时,抗肥胖药物(AOM)与VLCD联合使用时,作为辅助治疗显示出了前景。
本研究旨在探讨在综合生活方式计划中,辅助使用AOM对体重减轻和体重反弹的影响。
这是一项对参加VLCD/TMR计划(具体为OPTIFAST计划)的肥胖患者进行的回顾性研究。
分析了206例患者的数据(68%为女性,平均年龄52.39±13.05岁,BMI为41.71±7.04kg/m²)。其中,139例未接受AOM(AOM-),67例接受了AOM(AOM+)。6个月和18个月时的总体重减轻百分比(TWL%)分别为-17.87%±7.02和-12.10%±11.56。AOM组之间6个月体重减轻无显著差异。然而,与AOM-组相比,AOM+组的体重反弹较低(3.29kg±10.19 vs. 7.61kg±11.96;P=0.006),体重反弹百分比(WR%)也较低(31.5%±68.7 vs. 52.16%±64.4;P=0.04)。
研究结果突出了AOM和VLCD/TMR作为肥胖个体长期体重管理有效策略的潜力。