Tungalag Tsendsuren, Park Jung Yong, Park Kye Won, Yang Dong Kwon
Department of Veterinary Pharmacology and Toxicology, College of Veterinary Medicine, Jeonbuk National University, Iksan, Jeollabuk-do 54596 Republic of Korea.
Queensbucket, Daegudae-ro, Jillyang-eup, Gyeongsan-si, Gyeongsangbuk-do 38453 Republic of Korea.
Food Sci Biotechnol. 2023 Jul 12;33(3):699-709. doi: 10.1007/s10068-023-01367-1. eCollection 2024 Feb.
Inflammatory bowel disease (IBD) is a chronic inflammatory disease occurring in the gut causing chronic diarrhea and abdominal pain with severe complications. Sesame cake is a by-product of sesame oil production, possessing various beneficial properties; however, little is known about the effect of sesame cake extract (SCE) against IBD. The aim of this study was to investigate the protective effect of SCE against dextran sulfate sodium (DSS)-induced colitis in mice. Administration of SCE was first performed at 7 days before treating mice with 2.5% DSS to induce colitis for 7 days. SCE pretreatment improved symptoms of DSS-induced colitis. In addition, SCE ameliorated histopathological damages of the mucus layer in colon tissues and decreased pro-inflammatory cytokines in colitis-induced mice. SCE also suppressed apoptosis and oxidative stress in colitis-induced colon tissues. Together, these findings suggest that SCE could be potential nutraceuticals for treating colitis.
The online version contains supplementary material available at 10.1007/s10068-023-01367-1.
炎症性肠病（IBD）是一种发生在肠道的慢性炎症性疾病，可导致慢性腹泻和腹痛，并伴有严重并发症。芝麻饼是芝麻油生产的副产品，具有多种有益特性；然而，关于芝麻饼提取物（SCE）对IBD的影响知之甚少。本研究的目的是探讨SCE对葡聚糖硫酸钠（DSS）诱导的小鼠结肠炎的保护作用。在用2.5% DSS诱导小鼠结肠炎7天前7天开始给予SCE。SCE预处理改善了DSS诱导的结肠炎症状。此外，SCE减轻了结肠组织黏液层的组织病理学损伤，并降低了结肠炎诱导小鼠体内的促炎细胞因子。SCE还抑制了结肠炎诱导的结肠组织中的细胞凋亡和氧化应激。总之，这些发现表明SCE可能是治疗结肠炎的潜在营养保健品。
在线版本包含可在10.1007/s10068-023-01367-1获取的补充材料。
