Wachter R M
Arch Intern Med. 1987 Mar;147(3):556-8.
The optimal acute treatment for severe hypertension remains controversial. In the last few years, the use of sublingual and oral nifedipine has been supported by a growing literature and clinical experience. Most reviews have minimized the risk of hypotension caused by nifedipine therapy. This report describes three patients who developed profound hypotension after acute treatment of hypertension with the usual doses of nifedipine. A review of the literature reveals no previous reports of symptomatic hypotension from the use of nifedipine alone in this setting. Clinicians should be aware of this potentially life-threatening toxicity and titrate doses and monitor patients accordingly.
重度高血压的最佳急性治疗方法仍存在争议。在过去几年中，越来越多的文献和临床经验支持舌下含服和口服硝苯地平。大多数综述都将硝苯地平治疗引起的低血压风险降至最低。本报告描述了3例患者，他们在使用常规剂量硝苯地平急性治疗高血压后出现了严重低血压。文献回顾显示，此前尚无关于在此种情况下单独使用硝苯地平导致症状性低血压的报道。临床医生应意识到这种潜在的危及生命的毒性，并相应地调整剂量和监测患者。
