Lee Hye-Eun, Lee Jongin, Jang Tae-Won, Kim In-Ah, Park Jungsun, Song Jaechul
1Department of Occupational and Environmental Medicine, Kyung Hee University Hospital, Dongdaemun-gu Kyunghee-daero 23, Seoul, Republic of Korea.
2Department of Occupational and Environmental Medicine, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
Ann Occup Environ Med. 2018 Feb 6;30:11. doi: 10.1186/s40557-018-0221-4. eCollection 2018.
Since the International Agency for Research on Cancer classified shift work that involves circadian disruption as "probably carcinogenic to humans," there has been growing concern on the relationship between night work and breast cancer. In Korea, about 10-15% of workers are engaged in night-shift work, and breast cancer is one of the most common cancers in women. The purpose of this study was to review epidemiologic evidence on the relationship between night work and breast cancer.
We reviewed 21 original articles and 5 meta analyses on relationship between nightwork and breast cancer, and investigated the compensation criteria of Denmark.
The association between breast cancer and night work has been reported by numerous epidemiologic studies, including cohort studies, case-control studies, and meta-analysis. However, a dose-response relationship has not clearly emerged among workers exposed to less than 20 years of night work.
Although there are some limitations to the epidemiological studies so far, further consideration of breast cancer cases in patients with high exposure to night work is needed to assess breast cancer as a work-related disease.
自从国际癌症研究机构将涉及昼夜节律紊乱的轮班工作归类为“可能对人类致癌”以来，人们对夜班工作与乳腺癌之间的关系越来越关注。在韩国，约10%-15%的工人从事夜班工作，而乳腺癌是女性中最常见的癌症之一。本研究的目的是回顾关于夜班工作与乳腺癌之间关系的流行病学证据。
我们回顾了21篇关于夜班工作与乳腺癌关系的原创文章和5篇荟萃分析，并调查了丹麦的补偿标准。
包括队列研究、病例对照研究和荟萃分析在内的众多流行病学研究均报告了乳腺癌与夜班工作之间的关联。然而，在从事夜班工作少于20年的工人中，尚未明确出现剂量反应关系。
尽管迄今为止的流行病学研究存在一些局限性，但仍需要进一步考虑夜班工作高暴露患者的乳腺癌病例，以评估乳腺癌是否为与工作相关的疾病。
