肌少症在非洲的流行情况:观察性研究的系统评价和荟萃分析。

Prevalence of sarcopenia in Africa: a systematic review and meta-analysis of observational studies.

机构信息

Department of Internal Medicine, Geriatrics Section, University of Palermo, Palermo, Italy.

Centre for Health Performance and Wellbeing, Anglia Ruskin University, Cambridge, UK.

出版信息

Aging Clin Exp Res. 2024 Jan 28;36(1):12. doi: 10.1007/s40520-023-02671-w.

Abstract

BACKGROUND

Existing literature suggests that sarcopenia is a highly prevalent condition in older people. However, most studies to date reporting data on its prevalence have been mainly carried out in Western countries, while data on sarcopenia in Africa is scarce. With this systematic review and meta-analysis, we aimed to determine the prevalence of sarcopenia in African countries and to explore potential factors that could explain higher or lower prevalence of this condition in Africa.

METHODS

Major databases for studies reporting data on sarcopenia in African countries were searched from inception to June 2023. We conducted a meta-analysis of the prevalence [and 95% confidence intervals (95% CIs)] of sarcopenia in Africa, applying a random effect model. Several sensitivity and meta-regression analyses were run.

RESULTS

Among 147 articles initially screened, six articles (with seven cohorts) including a total of 10,656 participants were included. Mean age of participants was 66.9 years, and the majority were female (58.1%). The weighted prevalence of sarcopenia in the selected countries of Africa was 25.72% (95%CI: 18.90-32.55). This outcome was characterized by a high heterogeneity (I = 99%) and by publication bias. Among the factors investigated, sarcopenia was lower when assessed using only one anthropometric measure, or in South Africa.

CONCLUSION

Sarcopenia is a prevalent condition in Africa and thus research regarding this topic is a public health priority. Future studies that cover African countries for which data are not available and using standardized criteria are needed.

摘要

背景

现有文献表明,肌少症在老年人中是一种高发疾病。然而,迄今为止报告其流行率的数据的大多数研究主要在西方国家进行,而关于非洲肌少症的数据却很少。通过本次系统评价和荟萃分析,我们旨在确定非洲国家肌少症的流行率,并探讨可能导致该疾病在非洲流行率较高或较低的潜在因素。

方法

从研究开始到 2023 年 6 月,我们检索了主要数据库,以查找报告非洲国家肌少症数据的研究。我们对非洲肌少症的流行率[和 95%置信区间 (95%CI)]进行了荟萃分析,应用随机效应模型。进行了几项敏感性和荟萃回归分析。

结果

在最初筛选的 147 篇文章中,有 6 篇文章(共 7 个队列)纳入了 10656 名参与者。参与者的平均年龄为 66.9 岁,其中大多数为女性(58.1%)。选定的非洲国家肌少症的加权流行率为 25.72%(95%CI:18.90-32.55)。该结果表现出高度异质性(I=99%)和发表偏倚。在所研究的因素中,仅使用一种人体测量指标评估或在南非评估时,肌少症的流行率较低。

结论

肌少症在非洲是一种高发疾病,因此该主题的研究是公共卫生的重点。需要涵盖尚无数据的非洲国家并使用标准化标准的未来研究。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ee9/10822818/82a363df5bd3/40520_2023_2671_Fig1_HTML.jpg

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