College of Pharmacy, Anhui University of Chinese Medicine, Hefei 230012, China.
Anhui Institute for Food and Drug Control, Hefei 230051, China.
Food Funct. 2024 Feb 19;15(4):1737-1757. doi: 10.1039/d3fo03503d.
Extracellular vesicles (EVs) are nanoscale luminal vesicles that participate in the information transfer of proteins, nucleic acids, and lipids between cells, thereby playing a role in the treatment of diseases and the delivery of nutrients. In recent years, plant-derived EVs (PDEVs) containing bioactive compounds have attracted increasing interest due to their better biocompatibility and lower cytotoxicity in healthy tissues. In the biomedical field, PDEVs have been used as cargo carriers to achieve various functions through engineering modification techniques. This review focuses on the biogenesis, isolation, and identification of PDEVs. We discuss the surface functionalization of PDEVs to enhance therapeutic efficacy, thereby improving their efficiency as a next-generation drug delivery vehicle and their feasibility to treat diseases across the physiological barriers, while critically analyzing the current challenges and opportunities.
细胞外囊泡（EVs）是参与细胞间蛋白质、核酸和脂质信息传递的纳米级腔室囊泡，从而在疾病治疗和营养物质传递中发挥作用。近年来，由于在健康组织中具有更好的生物相容性和更低的细胞毒性，含有生物活性化合物的植物源性 EVs（PDEVs）引起了越来越多的关注。在生物医学领域，PDEVs 已被用作载药系统，通过工程修饰技术实现各种功能。本综述重点讨论了 PDEVs 的生物发生、分离和鉴定。我们讨论了 PDEVs 的表面功能化，以增强治疗效果，从而提高其作为下一代药物递送载体的效率，以及穿越生理屏障治疗疾病的可行性，同时批判性地分析了当前的挑战和机遇。
