University Pharmacy Department of Pharmacy Administration, Semmelweis University, Hőgyes Endre Street 7-9, 1092 Budapest, Hungary.
Int J Mol Sci. 2024 Jul 10;25(14):7559. doi: 10.3390/ijms25147559.
This systematic review offers a comprehensive analysis of plant-derived extracellular vesicles (PDEVs) as emerging drug delivery systems, focusing on original research articles published between 2016 and 2024 that exclusively examine the use of PDEVs for drug delivery. After a rigorous search across multiple databases, 20 relevant studies out of 805 initial results were selected for analysis. This review systematically summarizes the critical data on PDEV components, isolation methods, and drug-loading techniques. It highlights the potential of PDEVs to significantly enhance drug safety and efficacy, reduce dosage and toxicity, and align drug development with sustainable and environmentally friendly biotechnological processes. This review also emphasizes the advantages of PDEVs over mammalian-derived vesicles, such as cost-effectiveness, higher yield, and reduced immunogenicity. Additionally, it explores the synergistic potential between encapsulated drugs and bioactive compounds naturally present in PDEVs. This study acknowledges the challenges in standardizing isolation and formulation methods for clinical use. Overall, this review provides valuable insights into the current state and future directions of PDEV-based drug delivery systems, highlighting their promising role in advancing pharmaceutical research and development.
本系统评价全面分析了植物来源的细胞外囊泡（PDEV）作为新兴的药物传递系统，重点关注了 2016 年至 2024 年期间发表的原始研究文章，这些文章专门研究了 PDEV 用于药物传递的用途。在对多个数据库进行严格搜索后，从 805 个初始结果中选择了 20 项相关研究进行分析。本综述系统总结了 PDEV 成分、分离方法和药物加载技术的关键数据。它强调了 PDEV 提高药物安全性和疗效、降低剂量和毒性、使药物开发与可持续和环保的生物技术过程保持一致的潜力。本综述还强调了 PDEV 相对于哺乳动物来源的囊泡的优势，例如成本效益高、产量更高和免疫原性降低。此外，它还探讨了封装药物与 PDEV 中天然存在的生物活性化合物之间的协同潜力。本研究承认在临床应用中标准化分离和配方方法的挑战。总的来说，本综述提供了对基于 PDEV 的药物传递系统的现状和未来方向的宝贵见解，强调了它们在推进药物研究和开发方面的有前途的作用。
