Kim Manho, Jang Hyejun, Kim Wijin, Kim Doyeon, Park Ju Hyun
Department of Biomedical Science, Kangwon National University, Chuncheon-si 24341, Republic of Korea.
Antioxidants (Basel). 2023 Jun 16;12(6):1286. doi: 10.3390/antiox12061286.
Extracellular vesicles (EVs) composed of a lipid bilayer are released from various cell types, including animals, plants, and microorganisms, and serve as important mediators of cell-to-cell communication. EVs can perform a variety of biological functions through the delivery of bioactive molecules, such as nucleic acids, lipids, and proteins, and can also be utilized as carriers for drug delivery. However, the low productivity and high cost of mammalian-derived EVs (MDEVs) are major barriers to their practical clinical application where large-scale production is essential. Recently, there has been growing interest in plant-derived EVs (PDEVs) that can produce large amounts of electricity at a low cost. In particular, PDEVs contain plant-derived bioactive molecules such as antioxidants, which are used as therapeutic agents to treat various diseases. In this review, we discuss the composition and characteristics of PDEVs and the appropriate methods for their isolation. We also discuss the potential use of PDEVs containing various plant-derived antioxidants as replacements for conventional antioxidants.
由脂质双层组成的细胞外囊泡（EVs）从包括动物、植物和微生物在内的各种细胞类型中释放出来，并作为细胞间通讯的重要介质。细胞外囊泡可以通过传递生物活性分子（如核酸、脂质和蛋白质）来执行多种生物学功能，还可以用作药物递送的载体。然而，哺乳动物来源的细胞外囊泡（MDEVs）的低产量和高成本是其实际临床应用的主要障碍，而大规模生产在临床应用中至关重要。最近，人们对能够低成本大量生产的植物来源的细胞外囊泡（PDEVs）越来越感兴趣。特别是，植物来源的细胞外囊泡含有植物来源的生物活性分子，如抗氧化剂，这些抗氧化剂被用作治疗各种疾病的治疗剂。在这篇综述中，我们讨论了植物来源的细胞外囊泡的组成和特性以及分离它们的合适方法。我们还讨论了含有各种植物来源抗氧化剂的植物来源的细胞外囊泡作为传统抗氧化剂替代品的潜在用途。
