Department of Pathology, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China.
Department of Rehabilitation, The Second Affiliated Hospital of Shandong First Medical University, Taian, Shandong, 271000, China.
J Nanobiotechnology. 2023 Mar 29;21(1):114. doi: 10.1186/s12951-023-01858-7.
The past few years have witnessed a significant increase in research related to plant-derived extracellular vesicles (PDEVs) in biological and medical applications. Using biochemical technologies, multiple independent groups have demonstrated the important roles of PDEVs as potential mediators involved in cell-cell communication and the exchange of bio-information between species. Recently, several contents have been well identified in PDEVs, including nucleic acids, proteins, lipids, and other active substances. These cargoes carried by PDEVs could be transferred into recipient cells and remarkably influence their biological behaviors associated with human diseases, such as cancers and inflammatory diseases. This review summarizes the latest updates regarding PDEVs and focuses on its important role in nanomedicine applications, as well as the potential of PDEVs as drug delivery strategies to develop diagnostic and therapeutic agents for the clinical management of diseases, especially like cancers.
Considering its unique advantages, especially high stability, intrinsic bioactivity and easy absorption, further elaboration on molecular mechanisms and biological factors driving the function of PDEVs will provide new horizons for the treatment of human disease.
过去几年，植物来源的细胞外囊泡（PDEVs）在生物和医学应用方面的研究显著增加。多个独立的研究小组利用生化技术证明了 PDEVs 作为潜在的细胞间通讯介质和物种间生物信息交换的重要作用。最近，人们已经很好地鉴定出 PDEVs 中的多种物质，包括核酸、蛋白质、脂质和其他活性物质。PDEVs 携带的这些货物可以被转移到受体细胞中，并显著影响与人类疾病（如癌症和炎症性疾病）相关的生物学行为。本综述总结了 PDEVs 的最新研究进展，并重点介绍了其在纳米医学应用中的重要作用，以及 PDEVs 作为药物传递策略的潜力，用于开发用于疾病临床管理的诊断和治疗药物，特别是癌症。
鉴于其独特的优势，特别是高稳定性、内在生物活性和易于吸收，进一步阐述驱动 PDEVs 功能的分子机制和生物学因素将为人类疾病的治疗提供新的视野。
