Sitton N G, Dixon J S, Bird H A, Wright V
Br J Rheumatol. 1987 Apr;26(2):131-5. doi: 10.1093/rheumatology/26.2.131.
Most arthritic conditions are characterized by chronic inflammation, resulting in secondary changes in serum biochemistry. In an attempt to profile different mechanisms of inflammation which might account for the clinical diversity of rheumatic diseases, we have measured C-reactive protein (CRP), plasma viscosity, serum histidine and total serum sulphydryl in 259 patients with rheumatoid arthritis (RA), 84 with ankylosing spondylitis (AS), 76 with osteoarthritis, 69 with psoriatic arthritis, 34 with systemic lupus erythematosus (SLE), 36 with Reiter's syndrome and 121 normal controls. The most extreme abnormalities were seen in rheumatoid arthritis and the least in osteoarthritis. The seronegative spondarthritides and SLE occupied a midway position, emphasizing a correlation between biochemical abnormality and severity of inflammation. A low serum histidine characterized both RA and SLE. The former was more likely to be associated with a raised CRP. Plasma viscosity was characteristically raised in psoriatic arthritis and CRP in AS.
大多数关节炎病症的特点是慢性炎症，导致血清生化指标出现继发性变化。为了剖析可能导致风湿性疾病临床多样性的不同炎症机制，我们检测了259例类风湿关节炎（RA）患者、84例强直性脊柱炎（AS）患者、76例骨关节炎患者、69例银屑病关节炎患者、34例系统性红斑狼疮（SLE）患者、36例赖特综合征患者以及121名正常对照者的C反应蛋白（CRP）、血浆黏度、血清组氨酸和血清总巯基水平。类风湿关节炎患者出现的异常最为显著，而骨关节炎患者出现的异常最少。血清阴性脊柱关节炎和系统性红斑狼疮患者处于中间位置，这表明生化异常与炎症严重程度之间存在关联。血清组氨酸水平低是类风湿关节炎和系统性红斑狼疮的共同特征。前者更有可能与C反应蛋白升高有关。银屑病关节炎患者的血浆黏度通常会升高，而强直性脊柱炎患者的C反应蛋白会升高。
