Alpy Anastasia, Yusuff George, Simpson Troy, Dpt John Petrizzo, Dpt Michele Aquino, PhD Robert Otto, Wygand John
Department of Exercise Science, Adelphi University, Garden City NY, USA.
Int J Exerc Sci. 2023 Nov 1;16(3):1426-1439. doi: 10.70252/KAGH6991. eCollection 2023.
This study investigated the efficacy of topical cannabidiol (CBD) ointment in reducing localized inflammation, minimizing performance detriments, and attenuating soreness associated with delayed onset muscle soreness (DOMS). In a double blind randomized control trial, upper-arm circumferences, maximal voluntary isometric contractions (MVICs) for elbow flexion at 90° and 30° for college-aged participants ( = 21, age 20.8 ± 1.9 years) were assessed at baseline. Participants then performed a DOMS-inducing protocol for the biceps brachii. Topical CBD ointment and placebo (P) ointment were randomly assigned and applied 30 minutes, 24, 48 and 72 hours post the DOMS protocol. The baseline parameters and a visual analog scale (VAS) to assess perceived soreness were assessed 24, 48 and 72 hours post DOMS protocol. A 4x2 repeated measures factorial ANOVA ( < 0.05) analyzed both within and between subject differences. No changes were statistically significant on any days between conditions: Upper-arm circumferences in the CBD arm (7.1 ± 5.8 cm) and in the P arm (7.3 ± 5.8 cm). MVICs were reduced at both the 90° and 30° positions (-5.9 ± 9.0 Nm (90°)); (-4.8 ± 6.5 Nm (30°)) and the P arm (-5.0 ± 10.0 Nm (90°)); (-4.6 ± 5.3 Nm (30°)). Soreness increased in both the CBD arm (6.1 ± 2.1) and the P arm (5.5 ± 2.6) over time. Topical CBD therefore did not alter any parameters vs the P treatment, thus the use of topical CBD does not attenuate the effects of DOMS.
本研究调查了局部应用大麻二酚（CBD）软膏在减轻局部炎症、最小化运动能力损害以及减轻与延迟性肌肉酸痛（DOMS）相关的疼痛方面的疗效。在一项双盲随机对照试验中，对大学生参与者（n = 21，年龄20.8±1.9岁）的上臂周长、90°和30°时肘关节屈曲的最大自主等长收缩（MVIC）在基线时进行了评估。参与者随后进行了肱二头肌的DOMS诱导方案。局部CBD软膏和安慰剂（P）软膏被随机分配，并在DOMS方案后30分钟、24、48和72小时应用。在DOMS方案后24、48和72小时评估基线参数和用于评估疼痛感知的视觉模拟量表（VAS）。采用4×2重复测量析因方差分析（P < 0.05）分析组内和组间差异。各条件之间在任何一天均无统计学上的显著变化：CBD组的上臂周长（7.1±5.8 cm）和P组的上臂周长（7.3±5.8 cm）。在90°和30°位置MVIC均降低（-5.9±9.0 Nm（90°））；（-4.8±6.5 Nm（30°））以及P组（-5.0±10.0 Nm（90°））；（-4.6±5.3 Nm（30°））。随着时间推移，CBD组（6.1±2.1）和P组（5.5±2.6）的疼痛均增加。因此，与P治疗相比，局部应用CBD未改变任何参数，所以局部应用CBD并不能减轻DOMS的影响。
