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双缺陷富 Pt 超薄纳米线纳米酶通过清除活性氧物种来缓解炎症性皮肤病。

Twin defect-rich Pt ultrathin nanowire nanozymes alleviate inflammatory skin diseases by scavenging reactive oxygen species.

机构信息

Department of Dermatology, Xiangya Hospital, Central South University, Changsha, China; Hunan Key Laboratory of Aging Biology, Xiangya Hospital, Central South University, Changsha, China; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China.

College of Materials Science and Engineering, Hunan University, Changsha, Hunan, 410082, China.

出版信息

Redox Biol. 2024 Apr;70:103055. doi: 10.1016/j.redox.2024.103055. Epub 2024 Jan 23.

DOI:10.1016/j.redox.2024.103055
PMID:38290385
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10844124/
Abstract

Nanozymes with superior antioxidant properties offer new hope for treating oxidative stress-related inflammatory skin diseases. However, lacking sufficient catalytic activity or having complex material designs limit the application of current metallic nanozymes in inflammatory skin diseases. Here, we report a simple and effective twin-defect platinum nanowires (Pt NWs) enzyme with multiple mimetic enzymes and broad-spectrum ROS scavenging capability for the treatment of inflammatory skin diseases in mice (including psoriasis and rosacea). Pt NWs with simultaneous superoxide dismutase, glutathione peroxidase and catalase mimetic enzyme properties exhibit cytoprotective effects against ROS-mediated damage at extremely low doses and significantly improve treatment outcomes in psoriasis- and rosacea-like mice. Meanwhile, these ultrasmall sizes of Pt NWs allow the nanomaterials to effectively penetrate the skin and do not produce significant biotoxicity. Therefore, Pt NWs have potential applications in treating diseases related to oxidative stress or inflammation.

摘要

具有优越抗氧化性能的纳米酶为治疗与氧化应激相关的炎症性皮肤病带来了新的希望。然而，目前金属纳米酶由于缺乏足够的催化活性或具有复杂的材料设计，限制了其在炎症性皮肤病中的应用。在这里，我们报道了一种简单有效的双缺陷铂纳米线（Pt NWs）酶，它具有多种模拟酶和广谱 ROS 清除能力，可用于治疗小鼠的炎症性皮肤病（包括银屑病和酒渣鼻）。具有超氧化物歧化酶、谷胱甘肽过氧化物酶和过氧化氢酶模拟酶特性的 Pt NWs 在极低剂量下表现出对 ROS 介导的损伤的细胞保护作用，并显著改善了银屑病样和酒渣鼻样小鼠的治疗效果。同时，这些超小尺寸的 Pt NWs 使纳米材料能够有效地穿透皮肤，并且不会产生明显的生物毒性。因此，Pt NWs 在治疗与氧化应激或炎症相关的疾病方面具有潜在的应用前景。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b11d/10844124/7067d49fa4e5/gr10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b11d/10844124/34137f199f64/sc1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b11d/10844124/9be2bbf5632d/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b11d/10844124/7022c754ec0a/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b11d/10844124/1bbd1ef2097b/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b11d/10844124/c3d2e8895f1d/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b11d/10844124/aeaf5186a606/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b11d/10844124/a688517754c3/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b11d/10844124/9e0b413afe3b/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b11d/10844124/6ba79775742e/gr8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b11d/10844124/fe4bbfcd5c64/gr9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b11d/10844124/7067d49fa4e5/gr10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b11d/10844124/34137f199f64/sc1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b11d/10844124/9be2bbf5632d/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b11d/10844124/7022c754ec0a/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b11d/10844124/1bbd1ef2097b/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b11d/10844124/c3d2e8895f1d/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b11d/10844124/aeaf5186a606/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b11d/10844124/a688517754c3/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b11d/10844124/9e0b413afe3b/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b11d/10844124/6ba79775742e/gr8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b11d/10844124/fe4bbfcd5c64/gr9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b11d/10844124/7067d49fa4e5/gr10.jpg

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