Jayaraj A P, Tovey F I, Clark C G, Rees K R, White J S, Lewin M R
Clin Sci (Lond). 1987 Apr;72(4):463-6. doi: 10.1042/cs0720463.
The ulcerogenic and protective effects of various rice fractions in the diet were studied in the pylorus ligated ulcer model in the rat. Oil present in rice and particularly rice bran becomes ulcerogenic on storage and in this model results in a significant increase in the median (range) numbers of ulcers from six (one to ten) to nine (six to 15) (P less than 0.05). The ulcerogenic effect of stored rice bran oil was reversed by cysteine which significantly reduced the ulcer incidence from 100% to 60% (P less than 0.005) and the numbers of ulcers from 26 (six to 70) to one (zero to four) (P less than 0.001). Fresh rice bran significantly reduced the numbers of ulcers from six (one to ten) to one (one to four) (P less than 0.05). Similarly, unmilled rice and freshly milled newly harvested rice was also shown to be protective in this model by significantly reducing the ulcer incidence from 87.5% to 50% and 0% respectively (P values less than 0.025) and the numbers of ulcers from three (zero to 17) to one (zero to one) and zero (zero to zero) respectively (P values less than 0.001). These results could in part explain the geographical distribution of duodenal ulceration, where the incidence is high in all the rice eating areas of the world, and provide a plausible hypothesis to explain the mechanism of dietary ulcerogenesis.
在大鼠幽门结扎溃疡模型中研究了饮食中各种大米组分的致溃疡和保护作用。大米中存在的油脂，尤其是米糠，在储存时会产生致溃疡作用，在此模型中，溃疡中位数（范围）数量从6个（1至10个）显著增加至9个（6至15个）（P<0.05）。半胱氨酸可逆转储存米糠油的致溃疡作用，其显著降低溃疡发生率，从100%降至60%（P<0.005），溃疡数量从26个（6至70个）降至1个（0至4个）（P<0.001）。新鲜米糠显著降低溃疡数量，从6个（1至10个）降至1个（1至4个）（P<0.05）。同样，糙米和新收获的新鲜碾磨大米在该模型中也显示出保护作用，分别显著降低溃疡发生率，从87.5%降至50%和0%（P值<0.025），溃疡数量从3个（0至17个）分别降至1个（0至1个）和0个（0至0个）（P值<0.001）。这些结果可以部分解释十二指肠溃疡的地理分布情况，即在世界上所有食用大米的地区发病率都很高，并为解释饮食性溃疡发生机制提供一个合理的假设。
