Sadek Zahra, Salami Ali, Youness Mahmoud, Awada Charifa, Hamade Malek, Joumaa Wissam H, Ramadan Wiam, Ahmaidi Said
Laboratory EA-3300 (APERE) « Adaptations Physiologiques à l'Exercice et Réadaptation à l'Effort », Picardie Jules Verne University, Amiens, France.
Rammal Hassan Rammal Research Laboratory, Physio-toxicity (PhyTox) Research Group, Faculty of Sciences (V), Lebanese University, Nabatieh, Lebanon.
Chronic Illn. 2022 Mar;18(1):140-154. doi: 10.1177/1742395320920700. Epub 2020 May 5.
Chronic heart failure is a major public health problem in which supervised exercise programs are recommended as part of non-pharmacological management. There are various reports of the success of high-intensity aerobic interval training (HI-AIT) and inspiratory muscle training (IMT) in the management of chronic heart failure patients. This study tested the hypothesis that the combination of HI-AIT and IMT could result in additional benefits over the IMT and the HI-AIT alone in terms of inspiratory muscle function, exercise capacity, and quality of life in patients with chronic heart failure and inspiratory muscle weakness.
Forty patients with ejection fraction ≤45% and inspiratory muscle weakness described by maximal inspiratory pressure <70% predicted, underwent three exercise training sessions per week for 12 weeks. Patients were randomly allocated to one of four groups: the HI-AIT group, the IMT group, the combined (HI-AIT & IMT) group, and the control group. Before and after completing their training period, all patients underwent different tests that are mentioned above.
No changes were detected in the control group. However, the combined group, when compared to HI-AIT and IMT groups, respectively, resulted in additional significant improvement in maximal inspiratory training (62%, 24%, 25%), exercise time (62%, 29%, 12%), the 6-minute walk test (23%, 15%, 18%), and the Minnesota Living with Heart Failure Questionnaire (56%, 47%, 36%).
In patients with chronic heart failure and inspiratory muscle weakness, the combination of the HI-AIT and the IMT resulted in additional benefits in respiratory muscle function, exercise performance, and quality of life compared to that of HI-AIT or IMT alone.: NCT03538249.
慢性心力衰竭是一个重大的公共卫生问题，建议将监督下的运动计划作为非药物管理的一部分。有各种关于高强度有氧间歇训练（HI-AIT）和吸气肌训练（IMT）在慢性心力衰竭患者管理中取得成功的报道。本研究检验了这样一个假设，即对于慢性心力衰竭且伴有吸气肌无力的患者，HI-AIT和IMT相结合在吸气肌功能、运动能力和生活质量方面可能比单独的IMT和HI-AIT带来更多益处。
40例射血分数≤45%且最大吸气压力<预测值70%所描述的吸气肌无力患者，每周进行3次运动训练，共12周。患者被随机分配到四组之一：HI-AIT组、IMT组、联合（HI-AIT & IMT）组和对照组。在完成训练期前后，所有患者都接受了上述不同的测试。
对照组未检测到变化。然而，联合组与HI-AIT组和IMT组相比，分别在最大吸气训练（62%、24%、25%）、运动时间（62%、29%、12%）、6分钟步行试验（23%、15%、18%）和明尼苏达心力衰竭生活问卷（56%、47%、36%）方面有额外的显著改善。
对于慢性心力衰竭且伴有吸气肌无力的患者，与单独的HI-AIT或IMT相比，HI-AIT和IMT相结合在呼吸肌功能、运动表现和生活质量方面带来了更多益处。试验注册号：NCT03538249。
