尽管有直接口服抗凝剂，仍对缺血性脑卒中进行溶栓治疗。
Thrombolysis for ischaemic stroke despite direct oral anticoagulation.
机构信息
Department of Neurology, Heidelberg University Hospital, Heidelberg, Germany
Department of Neurology and Stroke Research Center Bern, Inselspital Bern, University of Bern, Bern, Switzerland.
出版信息
Stroke Vasc Neurol. 2024 Nov 5;9(5):464-466. doi: 10.1136/svn-2023-002727.
Intravenous thrombolysis is not recommended in anticoagulated patients receiving direct oral anticoagulants (DOACs) and a recent intake within the last 48 hours in US and European guidelines. However, three observational studies now suggest safety of thrombolysis in patients with recent intake of DOACs, and thus support previous experimental data. In this perspective, the current evidence and practical consequences are discussed.
在美国和欧洲的指南中，建议对于正在接受直接口服抗凝药物（DOACs）治疗且在最近 48 小时内有过近期摄入的抗凝患者，不进行静脉溶栓治疗。然而，三项观察性研究现在表明在近期摄入 DOACs 的患者中进行溶栓治疗是安全的，从而支持了之前的实验数据。在此背景下，讨论了当前的证据和实际后果。
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