Orellana V Diego, Donoghue John P, Vargas-Irwin Carlos E
Engineering Faculty, Pontificia Universidad Javeriana, Bogotá 110231, Colombia.
Faculty of Energy, Universidad Nacional de Loja, Loja 110101, Ecuador.
iScience. 2023 Oct 28;27(2):108310. doi: 10.1016/j.isci.2023.108310. eCollection 2024 Feb 16.
Local field potentials (LFPs) in the primate motor cortex have been shown to reflect information related to volitional movements. However, LFPs are composite signals that receive contributions from multiple neural sources, producing a complex mix of component signals. Using a blind source separation approach, we examined the components of neural activity recorded using multielectrode arrays in motor areas of macaque monkeys during a grasping and lifting task. We found a set of independent components in the low-frequency LFP with high temporal and spatial consistency associated with each task stage. We observed that ICs often arise from electrodes distributed across multiple cortical areas and provide complementary information to external behavioral markers, specifically in task stage detection and trial alignment. Taken together, our results show that it is possible to separate useful independent components of the LFP associated with specific task-related events, potentially representing internal markers of transition between cortical network states.
灵长类运动皮层的局部场电位（LFPs）已被证明能反映与自主运动相关的信息。然而，LFPs是复合信号，它接收来自多个神经源的贡献，产生成分信号的复杂混合。我们使用盲源分离方法，研究了猕猴运动区域在抓握和提起任务期间使用多电极阵列记录的神经活动成分。我们在低频LFP中发现了一组具有高时空一致性的独立成分，与每个任务阶段相关。我们观察到，独立成分通常来自分布在多个皮质区域的电极，并为外部行为标记提供补充信息，特别是在任务阶段检测和试验对齐方面。综上所述，我们的结果表明，有可能分离出与特定任务相关事件相关的有用的LFP独立成分，这些成分可能代表皮质网络状态之间转换的内部标记。
