Shamaitijiang Xiatiguli, Kimita Wandia, Ko Juyeon, Skudder-Hill Loren, Liu Yutong, Petrov Maxim S
School of Medicine, University of Auckland, Auckland, New Zealand.
J Clin Exp Hepatol. 2024 May-Jun;14(3):101343. doi: 10.1016/j.jceh.2023.101343. Epub 2023 Dec 28.
Liver is well recognised as a metabolically active organ. While intra-pancreatic fat deposition (IPFD) is emerging as an important player in the whole-body metabolism, the interplay between the liver and IPFD has been poorly investigated. This study aimed to investigate the associations of liver blood tests and non-invasive tests for hepatic fibrosis with IPFD.
Participants underwent a 3.0 Tesla magnetic resonance imaging to measure IPFD and map liver T1 (longitudinal relaxation time). Four liver tests were done on the same sample of blood. Hepatic fibrosis risk score (BARD) was calculated. Linear regression models were built, accounting for age, sex, visceral-to-subcutaneous fat ratio, and other covariates.
A total of 143 individuals were studied. In the most adjusted model, alkaline phosphatase ( < 0.001), alanine aminotransferase ( < 0.001), and γ-glutamyl transferase ( = 0.042) were significantly positively associated with IPFD. The BARD score was not significantly associated with IPFD in the most adjusted model ( = 0.295). T1 relaxation time of the liver was not significantly associated with IPFD in the most adjusted model ( = 0.782).
Elevated alkaline phosphatase, alanine aminotransferase, and γ-glutamyl transferase are associated with increased IPFD. Hepatic fibrosis does not appear to be associated with IPFD.
肝脏是公认的代谢活跃器官。虽然胰腺内脂肪沉积（IPFD）在全身代谢中逐渐成为一个重要因素，但肝脏与IPFD之间的相互作用尚未得到充分研究。本研究旨在探讨肝脏血液检查及肝纤维化非侵入性检查与IPFD之间的关联。
参与者接受3.0特斯拉磁共振成像以测量IPFD并绘制肝脏T1（纵向弛豫时间）图。对同一份血液样本进行四项肝脏检查。计算肝纤维化风险评分（BARD）。建立线性回归模型，纳入年龄、性别、内脏与皮下脂肪比例及其他协变量。
共研究了143名个体。在调整最充分的模型中，碱性磷酸酶（<0.001）、丙氨酸氨基转移酶（<0.001）和γ-谷氨酰转移酶（=0.042）与IPFD显著正相关。在调整最充分的模型中，BARD评分与IPFD无显著关联（=0.295）。在调整最充分的模型中，肝脏T1弛豫时间与IPFD无显著关联（=0.782）。
碱性磷酸酶、丙氨酸氨基转移酶和γ-谷氨酰转移酶升高与IPFD增加有关。肝纤维化似乎与IPFD无关。
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