Jian Zhijie, Meng Zixuan, Yao Guolin, Liu Hui, Yang Jian, Wu Yue, Liu Wenjun, Cheng Lele
Department of Medical Imaging, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, P.R. China.
Department of Cardiovascular Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, P.R. China.
J Nutr Health Aging. 2024 Mar;28(3):100167. doi: 10.1016/j.jnha.2024.100167. Epub 2024 Feb 1.
Low muscle mass is related to cardiovascular risk factors. This study aimed to investigate whether relative low muscle mass is related to the diameter and tortuosity of the aorta.
We performed a cross-sectional study of 208 adults without known cardiovascular disease who underwent Computed Tomography (CT) enhanced scan between 2020 and 2021. Skeletal muscle index (SMI) was estimated. The morphology of the aorta was measured by diameter and tortuosity using CT. We assessed the relationship between SMI and diameter and tortuosity of the aorta using Spearman correlation analysis and univariate and multivariate-adjusted regression models.
Of all -individuals, 124 (59.6%) were male. The average age was 60.13 ± 16.33 years old. SMI was inversely associated with the diameter and tortuosity of the aorta (p < 0.05). Specifically, in a multivariable-adjusted model adjusting for potential confounders, a one-unit increase in the SMI was associated with a -13.56mm(95% confidence intervals (CI): -18.16 to -8.96, p < 0.001), -7.93 mm (95% CI: -10.85 to -5.02, p < 0.001), -8.01 mm (95% CI: -11.30 to -4.73, p < 0.001), -5.16 mm (95% CI: -7.57 to -2.75, p < 0.001) and -2.73 mm (95% CI: -5.18 to -0.27, p = 0.031) increase in L1-L5 diameter respectively, a -0.89 (95% CI: -1.14 to -0.64, p < 0.001) increase in the aorta tortuosity, a -0.48 (95% CI: -0.59 to -0.36, p < 0.001) increase in the descending thoracic aorta tortuosity, and a -0.44 (95% CI: -0.52 to -0.35, p < 0.001) increase in the abdominal aorta tortuosity.
Relative muscle mass was negatively associated with the diameter and tortuosity of the aorta, suggesting muscle mass maintenance may play a role in preventing aortic morphological changes.
低肌肉量与心血管危险因素相关。本研究旨在调查相对低肌肉量是否与主动脉直径和迂曲度有关。
我们对208名无已知心血管疾病的成年人进行了一项横断面研究，这些人在2020年至2021年间接受了计算机断层扫描（CT）增强扫描。估算骨骼肌指数（SMI）。使用CT通过直径和迂曲度测量主动脉形态。我们使用Spearman相关性分析以及单变量和多变量调整回归模型评估SMI与主动脉直径和迂曲度之间的关系。
在所有个体中，124名（59.6%）为男性。平均年龄为60.13±16.33岁。SMI与主动脉直径和迂曲度呈负相关（p<0.05）。具体而言，在调整潜在混杂因素的多变量调整模型中，SMI每增加一个单位，分别与L1-L5直径增加-13.56mm（95%置信区间（CI）：-18.16至-8.96，p<0.001）、-7.93mm（95%CI：-10.85至-5.02，p<0.001）、-8.01mm（95%CI：-11.30至-4.73，p<0.001）、-5.16mm（95%CI：-7.57至-2.75，p<0.001）和-2.73mm（95%CI：-5.18至-0.27，p=0.031）相关，与主动脉迂曲度增加-0.89（95%CI：-1.14至-0.64，p<0.001）、降主动脉迂曲度增加-0.48（95%CI：-0.59至-0.36，p<0.001）以及腹主动脉迂曲度增加-0.44（95%CI：-0.52至-0.35，p<双<0.001）相关。
相对肌肉量与主动脉直径和迂曲度呈负相关，提示维持肌肉量可能在预防主动脉形态改变中起作用。
