Department of Applied Mathematics, University of Dhaka, Dhaka, 1000, Bangladesh.
Department of Electronic Engineering and Information Science, University of Science and Technology of China, Hefei, 230027, China.
Med Biol Eng Comput. 2024 May;62(5):1549-1567. doi: 10.1007/s11517-024-03017-y. Epub 2024 Feb 3.
Radiofrequency ablation is a nominally invasive technique to eradicate cancerous or non-cancerous cells by heating. However, it is still hampered to acquire a successful cell destruction process due to inappropriate RF intensities that will not entirely obliterate tumorous tissues, causing in treatment failure. In this study, we are acquainted with a nanoassisted RF ablation procedure of cardiac tumor to provide better outcomes for long-term survival rate without any recurrences. A three-dimensional thermo-electric energy model is employed to investigate nanothermal field and ablation efficiency into the left atrium tumor. The cell death model is adopted to quantify the degree of tissue injury while injecting the FeO nanoparticles concentrations up to 20% into the target tissue. The results reveal that when nanothermal field extents as a function of tissue depth (10 mm) from the electrode tip, the increasing thermal rates were approximately 0.54362%, 3.17039%, and 7.27397% for the particle concentration levels of 7%, 10%, and 15% compared with no-particle case. In the 7% FeO nanoparticles, 100% fractional damage index is achieved after ablation time of 18 s whereas tissue annihilation approach proceeds longer to complete for no-particle case. The outcomes indicate that injecting nanoparticles may lessen ablation time in surgeries and prevent damage to adjacent healthy tissue.
射频消融是一种通过加热来消除癌细胞或非癌细胞的微创技术。然而，由于射频强度不当，无法完全摧毁肿瘤组织，导致治疗失败，该技术仍难以获得成功的细胞破坏过程。在这项研究中，我们采用了一种纳米辅助射频消融技术来治疗心脏肿瘤，以期在不复发的情况下提高长期生存率。采用三维热电能量模型研究了纳米热场和消融效率在左心房肿瘤中的情况。采用细胞死亡模型来量化组织损伤程度，同时将 FeO 纳米颗粒浓度注射到目标组织中高达 20%。结果表明，当纳米热场随着从电极尖端到组织深度（10mm）的函数扩展时，与无颗粒情况相比，颗粒浓度分别为 7%、10%和 15%时，热率分别约为 0.54362%、3.17039%和 7.27397%。在 7%的 FeO 纳米颗粒中，消融时间为 18 秒时即可达到 100%的分数损伤指数，而无颗粒情况下组织破坏过程则需要更长时间才能完成。结果表明，注射纳米颗粒可能会减少手术中的消融时间，并防止对相邻健康组织的损伤。
