Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Republic of Korea; Asan Diabetes Center, Asan Medical Center, Seoul 05505, Republic of Korea.
Diabetes Res Clin Pract. 2024 Feb;208:111125. doi: 10.1016/j.diabres.2024.111125. Epub 2024 Feb 1.
In this study, we aimed to evaluate the impact of overall cardiovascular disease (CVD) risk on the development of incident T2DM in patients with prediabetes.
We retrospectively enrolled 5,908 subjects with prediabetes who underwent health check-ups at the Asan Medical Center. CVD risk was estimated using the Framingham Risk Score (FRS). We compared moderate- to high-risk groups with low-risk controls based on the FRS. Cox proportional hazards regressions were conducted to estimate the time-to-develop incident T2DM.
Among the 5908 subjects with prediabetes, 3031 (51.8 %) were identified to have either moderate or high CVD risk scores. During a median follow-up of 5.2 years, 278 (9.2 %) patients from the moderate- to high-risk group and 171 (5.9 %) from the low-risk group were diagnosed with T2DM. The covariate-adjusted hazard ratio for the incident T2DM was 1.30 (95 % CI, 1.06-1.60, p = 0.011) in the moderate- to high-risk group compared to the low-risk controls.
Among patients with prediabetes, those with high CVD risk were more likely to develop incident T2DM, as determined by the FRS. CVD risk factors should be properly evaluated and managed in individuals with prediabetes to reduce the risk of both incident T2DM and associated cardiovascular complications.
本研究旨在评估整体心血管疾病（CVD）风险对糖尿病前期患者发生 2 型糖尿病（T2DM）的影响。
我们回顾性纳入了在亚洲医疗中心接受健康检查的 5908 例糖尿病前期患者。使用 Framingham 风险评分（FRS）评估 CVD 风险。我们根据 FRS 将中高危组与低危组进行比较。使用 Cox 比例风险回归估计发生 T2DM 的时间。
在 5908 例糖尿病前期患者中，有 3031 例（51.8%）被确定为中危或高危 CVD 风险评分。在中位随访 5.2 年期间，中高危组有 278 例（9.2%）和低危组有 171 例（5.9%）患者被诊断为 T2DM。中高危组发生 T2DM 的校正后风险比为 1.30（95%可信区间，1.06-1.60，p=0.011）。
根据 FRS，糖尿病前期患者中 CVD 风险较高者发生 T2DM 的风险更高。应适当评估和管理糖尿病前期患者的 CVD 风险因素，以降低 T2DM 及相关心血管并发症的风险。
