Goyal Manish K, Solanki Ram K, Jain Akhilesh, Yadav Kuldeep S
Department of Psychiatry, SMS Medical College, Jaipur, Rajasthan, India.
Department of Psychiatry, ESIC Model Hospital, Jaipur, Rajasthan, India.
Indian J Psychiatry. 2023 Apr;65(4):465-468. doi: 10.4103/indianjpsychiatry.indianjpsychiatry_250_22. Epub 2023 Apr 11.
There are various factors including inflammation that have been studied in bipolar disorder. NLR (Neutrophil to lymphocyte ratio) and PLR (platelet to lymphocyte ratio) are one of them. Various psychotropic drugs can affect the inflammatory state.
This study was planned to find NLR and PLR in bipolar disorder (mania) and psychotropic drug naïve 1 episode mania.
Total of 120 subjects were chosen including, 40 bipolar mania, 40 drugs naïve 1 episode mania, and 40 healthy controls. The severity of mania was assessed by the Young Mania Rating Scale. Blood samples were collected in the morning hours in order to get blood counts.
A significantly higher values of neutrophil counts and NLR, while the significant lower values of lymphocyte counts in both 1 episode and bipolar mania compared to healthy control were observed. The first episode mania group had significantly higher neutrophil counts and NLR in comparison to bipolar mania.
Results suggest a possible inflammatory pathophysiology of mania. Psychotropic medicines may have an anti-inflammatory effect, signified by the fact that 1 episode mania group has a greater level of inflammation in comparison to bipolar mania.
在双相情感障碍中，人们研究了包括炎症在内的多种因素。中性粒细胞与淋巴细胞比值（NLR）和血小板与淋巴细胞比值（PLR）就是其中之一。各种精神药物会影响炎症状态。
本研究旨在测定双相情感障碍（躁狂发作）患者及未服用过精神药物的首次发作躁狂患者的NLR和PLR。
共选取120名受试者，包括40名双相躁狂患者、40名未服用过精神药物的首次发作躁狂患者和40名健康对照者。采用杨氏躁狂量表评估躁狂的严重程度。为进行血细胞计数，于上午采集血样。
与健康对照相比，首次发作躁狂组和双相躁狂组的中性粒细胞计数和NLR值显著更高，而淋巴细胞计数显著更低。与双相躁狂组相比，首次发作躁狂组的中性粒细胞计数和NLR显著更高。
结果提示躁狂可能存在炎症性病理生理学机制。精神药物可能具有抗炎作用，这表现为首次发作躁狂组比双相躁狂组具有更高的炎症水平。
