State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, 130022, Changchun, P. R. China.
School of Applied Chemistry and Engineering, University of Science and Technology of China, 230026, Hefei, P. R. China.
Angew Chem Int Ed Engl. 2024 Apr 24;63(18):e202401758. doi: 10.1002/anie.202401758. Epub 2024 Feb 22.
Sonodynamic therapy (SDT) has garnered growing interest owing to its high tissue penetration depth and minimal side effects. However, the lack of efficient sonosensitizers remains the primary limiting factor for the clinical application of this treatment method. Here, defect-repaired graphene phase carbon nitride (g-CN) nanosheets are prepared and utilized for enhanced SDT in anti-tumor treatment. After defect engineering optimization, the bulk defects of g-CN are significantly reduced, resulting in higher crystallinity and exhibiting a polyheptazine imide (PHI) structure. Due to the more extended conjugated structure of PHI, facilitating faster charge transfer on the surface, it exhibits superior SDT performance for inducing apoptosis in tumor cells. This work focuses on introducing a novel carbon nitride nanomaterial as a sonosensitizer and a strategy for optimizing sonosensitizer performance by reducing bulk defects.
声动力学疗法（SDT）由于其具有较高的组织穿透深度和最小的副作用而引起了越来越多的关注。然而，缺乏有效的声敏剂仍然是该治疗方法临床应用的主要限制因素。在这里，制备了缺陷修复的石墨烯相氮化碳（g-CN）纳米片，并将其用于增强抗肿瘤治疗中的 SDT。经过缺陷工程优化后，g-CN 的体相缺陷显著减少，结晶度更高，并呈现聚庚嗪亚胺（PHI）结构。由于 PHI 的共轭结构更加扩展，有利于表面更快的电荷转移，因此它在诱导肿瘤细胞凋亡方面表现出卓越的 SDT 性能。这项工作的重点是引入一种新型的氮化碳纳米材料作为声敏剂，并通过减少体相缺陷来优化声敏剂性能的策略。
