Shen Qiaoling, Yu Chunjing
Department of Nuclear Medicine, Affiliated Hospital of Jiangnan University, Wuxi, China.
Wuxi School of Medicine, Jiangnan University, Wuxi, China.
Front Bioeng Biotechnol. 2024 Jan 25;11:1323316. doi: 10.3389/fbioe.2023.1323316. eCollection 2023.
Multimodal imaging are approaches which combines multiple imaging techniques to obtain multi-aspect information of a target through different imaging modalities, thereby greatly improve the accuracy and comprehensiveness of imaging. Superparamagnetic iron oxide nanoparticles (SPIONs) modified with branched polyethyleneimine have revealed good biocompatibility and stability, high drug loading capacity and nucleic acid transfection efficiency. SPIONs have been developed as functionalized platforms which can be further modified to enhance their functionalities. Those further modifications facilitate the application of SPIONs in multimodal imaging. In this review, we discuss the methods, advantages, applications, and prospects of BPEI-modified SPIONs in multimodal imaging.
多模态成像方法是将多种成像技术结合起来，通过不同的成像方式获取目标的多方面信息，从而大大提高成像的准确性和全面性。用支化聚乙烯亚胺修饰的超顺磁性氧化铁纳米颗粒（SPIONs）已显示出良好的生物相容性和稳定性、高载药能力和核酸转染效率。SPIONs已被开发为功能化平台，可进一步修饰以增强其功能。这些进一步的修饰促进了SPIONs在多模态成像中的应用。在本综述中，我们讨论了BPEI修饰的SPIONs在多模态成像中的方法、优势、应用和前景。
