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炎症性肠病中粪便微生物群移植的当前观点

Current perspectives on fecal microbiota transplantation in inflammatory bowel disease.

作者信息

Singh Arshdeep, Midha Vandana, Chauhan Nar Singh, Sood Ajit

机构信息

Department of Gastroenterology, Dayanand Medical College and Hospital, Ludhiana, 141 001, India.

Department of Internal Medicine, Dayanand Medical College and Hospital, Ludhiana, 141 001, India.

出版信息

Indian J Gastroenterol. 2024 Feb;43(1):129-144. doi: 10.1007/s12664-023-01516-8. Epub 2024 Feb 9.


DOI:10.1007/s12664-023-01516-8
PMID:38334893
Abstract

Fecal microbiota transplantation (FMT) has emerged as a promising therapeutic modality within the domain of inflammatory bowel disease (IBD). While FMT has secured approval and demonstrated efficacy in addressing recurrent and refractory Clostridioides difficile infection, its application in IBD remains an area of active exploration and research. The current status of FMT in IBD reflects a nuanced landscape, with ongoing investigations delving into its effectiveness, safety and optimal implementation. Early-stage clinical trials and observational studies have provided insights into the potential of FMT to modulate the dysbiotic gut microbiota associated with IBD, aiming to mitigate inflammation and promote mucosal healing. However, considerable complexities persist, including variations in donor selection, treatment protocols and outcome assessments. Challenges in standardizing FMT protocols for IBD treatment are compounded by the dynamic nature of the gut microbiome and the heterogeneity of IBD itself. Despite these challenges, enthusiasm for FMT in IBD emanates from its capacity to address gut microbial dysbiosis, signifying a paradigm shift towards more comprehensive approaches in IBD management. As ongoing research progresses, an enhanced understanding of FMT's role in IBD therapy is anticipated. This article synthesizes the current status of FMT in IBD, elucidating the attendant challenges and aspiring towards the refinement of its application for improved patient outcomes.

摘要

粪便微生物群移植(FMT)已成为炎症性肠病(IBD)领域一种有前景的治疗方式。虽然FMT已获批并在治疗复发性和难治性艰难梭菌感染方面显示出疗效,但其在IBD中的应用仍是一个积极探索和研究的领域。FMT在IBD中的现状反映出一个微妙的局面,正在进行的调查深入研究其有效性、安全性和最佳实施方式。早期临床试验和观察性研究已对FMT调节与IBD相关的肠道微生物群失调的潜力提供了见解,旨在减轻炎症并促进黏膜愈合。然而,相当多的复杂性依然存在,包括供体选择、治疗方案和结果评估的差异。肠道微生物组的动态性质和IBD本身的异质性使IBD治疗的FMT方案标准化面临的挑战更加复杂。尽管存在这些挑战,但FMT在IBD中的应用前景源于其解决肠道微生物群失调的能力,这标志着IBD管理向更全面方法的范式转变。随着正在进行的研究不断推进,预计对FMT在IBD治疗中作用的理解将得到增强。本文综合了FMT在IBD中的现状,阐明了随之而来的挑战,并期望优化其应用以改善患者预后。

相似文献

[1]
Current perspectives on fecal microbiota transplantation in inflammatory bowel disease.

Indian J Gastroenterol. 2024-2

[2]
Changes in microbial ecology after fecal microbiota transplantation for recurrent C. difficile infection affected by underlying inflammatory bowel disease.

Microbiome. 2017-5-15

[3]
Microbial Engraftment and Efficacy of Fecal Microbiota Transplant for Clostridium Difficile in Patients With and Without Inflammatory Bowel Disease.

Inflamm Bowel Dis. 2019-5-4

[4]
FMT: What's Next? A Narrative Review of Fecal Microbiota Transplantation in Clostridioides difficile Infection and Inflammatory Bowel Disease.

R I Med J (2013). 2022-11-1

[5]
Inflammatory Bowel Disease Affects the Outcome of Fecal Microbiota Transplantation for Recurrent Clostridium difficile Infection.

Clin Gastroenterol Hepatol. 2016-10

[6]
Microbiome changes associated with sustained eradication of Clostridium difficile after single faecal microbiota transplantation in children with and without inflammatory bowel disease.

Aliment Pharmacol Ther. 2015-7-21

[7]
The Current Landscape and Lessons from Fecal Microbiota Transplantation for Inflammatory Bowel Disease: Past, Present, and Future.

Inflamm Bowel Dis. 2017-10

[8]
Fecal transplantation for treatment of inflammatory bowel disease.

Cochrane Database Syst Rev. 2018-11-13

[9]
The interplay of gut microbiota between donors and recipients determines the efficacy of fecal microbiota transplantation.

Gut Microbes. 2022

[10]
Fecal microbiota transplantation for recurrent C. difficile infection in patients with inflammatory bowel disease: experience of a large-volume European FMT center.

Gut Microbes. 2021

引用本文的文献

[1]
Intestinal Microbiota and Fecal Transplantation in Patients with Inflammatory Bowel Disease and : An Updated Literature Review.

J Clin Med. 2025-7-25

[2]
Microbiota-Host Interactions: Exploring Their Dynamics and Contributions to Human Diseases.

Microbiologyopen. 2025-8

[3]
Bacteriophage-driven DNA inversions shape bacterial functionality and long-term co-existence in .

Gut Microbes. 2025-12

[4]
Gut microbiota in Crohn's disease pathogenesis.

World J Gastroenterol. 2025-2-14

[5]
Advancing microbiota therapeutics: the role of synthetic biology in engineering microbial communities for precision medicine.

Front Bioeng Biotechnol. 2024-12-4

本文引用的文献

[1]
Anaerobic Feces Processing for Fecal Microbiota Transplantation Improves Viability of Obligate Anaerobes.

Microorganisms. 2023-9-5

[2]
Role of Diet-Microbiome Interaction in Gastrointestinal Disorders and Strategies to Modulate Them with Microbiome-Targeted Therapies.

Annu Rev Nutr. 2023-8-21

[3]
Fecal microbiota transplantation refurbishes the crypt-associated microbiota in ulcerative colitis.

iScience. 2023-4-23

[4]
Fecal transplantation for treatment of inflammatory bowel disease.

Cochrane Database Syst Rev. 2023-4-25

[5]
Faecal metabolome and its determinants in inflammatory bowel disease.

Gut. 2023-8

[6]
Fecal microbiota transplantation for induction of remission in Crohn's disease: a systematic review and meta-analysis.

Int J Colorectal Dis. 2023-3-8

[7]
A Systematic Review of Fecal Microbiota Transplant for the Management of Pouchitis.

Crohns Colitis 360. 2020-5-12

[8]
Specific fungi associated with response to capsulized fecal microbiota transplantation in patients with active ulcerative colitis.

Front Cell Infect Microbiol. 2022

[9]
A Matching Strategy To Guide Donor Selection for Ulcerative Colitis in Fecal Microbiota Transplantation: Meta-Analysis and Analytic Hierarchy Process.

Microbiol Spectr. 2023-2-14

[10]
Faecal microbiota transplantations and the role of bacteriophages.

Clin Microbiol Infect. 2023-6

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