Faculdade de Veterinária, Setor de Patologia Veterinária, Universidade Federal do Rio Grande do Sul, Rio Grande do Sul, Brazil.
J Vet Diagn Invest. 2024 Mar;36(2):278-282. doi: 10.1177/10406387231221115. Epub 2024 Feb 9.
We describe an unusual outbreak of mortality in suckling piglets following the misadministration of an oral vaccine against Typhimurium and Choleraesuis. Within 3-48 h of vaccination of a batch of ~700 piglets, ~300 developed marked swelling in the dorsal neck region, respiratory distress, fever, recumbency, and apathy. In total, ~100 died, and 4 were submitted for autopsy. Gross and microscopic lesions consisted of focally extensive areas of purple discoloration in the skin of the cervical region, associated with edema and hemorrhage in the subcutis and muscles. Additionally, there was interstitial pneumonia with marked interlobular edema and mild fibrinous pleuritis. Aerobic bacterial culture identified Typhimurium (3 cases) and Choleraesuis (1 case) in samples of skeletal muscle and lung and from pleural swab samples. Marked immunostaining against spp. was observed in the skeletal muscle of the cervical region, as well as in blood vessels and macrophages from the lung, liver, spleen, and kidney. We concluded that inappropriate intramuscular administration of an oral vaccine against resulted in septicemia and death in a batch of piglets.
我们描述了一起在误用针对肠炎沙门氏菌和猪霍乱沙门氏菌的口服疫苗后导致仔猪大量死亡的不寻常爆发事件。在对一批约 700 头仔猪进行接种后 3-48 小时内，约 300 头仔猪出现颈部背部区域明显肿胀、呼吸困难、发热、卧地不起和精神沉郁等症状。总共有约 100 头仔猪死亡，其中 4 头被提交进行剖检。大体和显微镜病变包括颈部皮肤的局灶性广泛紫斑区域，伴有皮下组织和肌肉的水肿和出血。此外，还存在间质性肺炎，伴有明显的小叶间水肿和轻度纤维性胸膜炎。需氧细菌培养从骨骼肌和肺以及胸腔拭子样本中鉴定出肠炎沙门氏菌（3 例）和猪霍乱沙门氏菌（1 例）。在颈部骨骼肌以及肺、肝、脾和肾的血管和巨噬细胞中观察到针对 spp. 的强烈免疫染色。我们得出结论，误用针对肠炎沙门氏菌的口服疫苗进行肌肉内注射导致了一批仔猪发生败血症和死亡。
