Institut Pasteur, Université Paris Cité, Arboviruses and Insect Vectors, Paris, France.
Université des Antilles, Ecole Doctorale 589, Schœlcher, Martinique, Marseille, France.
Nat Commun. 2024 Feb 9;15(1):1236. doi: 10.1038/s41467-024-45116-2.
The mosquito-borne disease, Yellow fever (YF), has been largely controlled via mass delivery of an effective vaccine and mosquito control interventions. However, there are warning signs that YF is re-emerging in both Sub-Saharan Africa and South America. Imported from Africa in slave ships, YF was responsible for devastating outbreaks in the Caribbean. In Martinique, the last YF outbreak was reported in 1908 and the mosquito Aedes aegypti was incriminated as the main vector. We evaluated the vector competence of fifteen Ae. aegypti populations for five YFV genotypes (Bolivia, Ghana, Nigeria, Sudan, and Uganda). Here we show that mosquito populations from the Caribbean and the Americas were able to transmit the five YFV genotypes, with YFV strains for Uganda and Bolivia having higher transmission success. We also observed that Ae. aegypti populations from Martinique were more susceptible to YFV infection than other populations from neighboring Caribbean islands, as well as North and South America. Our vector competence data suggest that the threat of re-emergence of YF in Martinique and the subsequent spread to Caribbean nations and beyond is plausible.
蚊媒疾病黄热病（YF）通过大规模接种有效疫苗和开展蚊虫控制干预措施得到了有效控制。然而，有迹象表明，黄热病在撒哈拉以南非洲和南美洲重新出现。黄热病通过奴隶船从非洲传入，在加勒比地区造成了毁灭性的疫情。在马提尼克岛，最后一次黄热病疫情发生在 1908 年，埃及伊蚊被认为是主要的传播媒介。我们评估了来自非洲和美洲的 15 种埃及伊蚊种群对五种黄病毒基因型（玻利维亚、加纳、尼日利亚、苏丹和乌干达）的媒介效能。研究结果表明，来自加勒比海和美洲的蚊子种群能够传播这五种黄病毒基因型，其中来自乌干达和玻利维亚的黄病毒株具有更高的传播成功率。我们还观察到，来自马提尼克岛的埃及伊蚊种群比来自加勒比地区其他岛屿以及北美和南美的其他种群更容易感染黄病毒。我们的媒介效能数据表明，黄热病在马提尼克岛重新出现并随后传播到加勒比国家及其他地区的威胁是合理的。
