Kobayashi Go, Imai Takeharu, Sentani Kazuhiro
Laboratory of Molecular Pathology, Department of Molecular Biosciences, Radiation Effects Research Foundation, Hiroshima 732-0815, Japan.
Department of Molecular Pathology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima 734-8551, Japan.
J Clin Med. 2024 Jan 23;13(3):658. doi: 10.3390/jcm13030658.
Gastric cancer (GC) is still one of the leading causes of cancer-related mortality. We previously reported the relationship between histological heterogeneity of tumor cells and molecular features in GC. The tumor microenvironment also has a crucial role in GC progression and therapeutic resistance. In this study, we focused on the tumor microenvironment, especially inflammatory cells in GC. Using GC tissue slides, we investigated the distribution and clinicopathological significance of inflammatory cell counts including eosinophils, neutrophils, lymphocytes, and plasma cells. Additionally, we investigated the relationship between Mott cells (plasma cells containing Russell bodies) and clinicopathological features. In neoplastic gastric mucosa, a high number of plasma cells was associated with low T-grade, early stage, and good prognosis. We then focused on Mott cells and found that their presence in neoplastic gastric mucosa was associated with lower T and N grades, early stage, and Helicobacter pylori infection and was inversely associated with CD44 and EGFR expression. Additionally, the presence of Mott cells was associated with good prognosis in advanced GC and was an independent favorable prognostic predictor. The presence of Mott cells in GC might be one useful prognostic predictor, and Mott cells might have an important role in the carcinogenesis of infection.
胃癌（GC）仍然是癌症相关死亡的主要原因之一。我们之前报道了GC中肿瘤细胞的组织学异质性与分子特征之间的关系。肿瘤微环境在GC进展和治疗耐药性中也起着关键作用。在本研究中，我们聚焦于肿瘤微环境，尤其是GC中的炎症细胞。利用GC组织切片，我们研究了包括嗜酸性粒细胞、中性粒细胞、淋巴细胞和浆细胞在内的炎症细胞计数的分布及其临床病理意义。此外，我们还研究了莫特细胞（含有拉塞尔小体的浆细胞）与临床病理特征之间的关系。在肿瘤性胃黏膜中，大量浆细胞与低T分级、早期阶段及良好预后相关。然后我们聚焦于莫特细胞，发现它们在肿瘤性胃黏膜中的存在与较低的T和N分级、早期阶段及幽门螺杆菌感染相关，且与CD44和表皮生长因子受体（EGFR）表达呈负相关。此外，莫特细胞的存在与晚期GC的良好预后相关，并且是一个独立的有利预后预测指标。GC中莫特细胞的存在可能是一个有用的预后预测指标，并且莫特细胞可能在感染致癌过程中发挥重要作用。
