Observatorio Epidemiológico de Nutrición y Enfermedades Crónicas, Nutrition School, Health Faculty, Universidad Industrial de Santander, Cra 32 # 29-31, Bucaramanga 680002, Colombia.
Colombian Corporation for Agricultural Research-Agrosavia, La Selva Research Center, Kilometer 7, Vía a Las Palmas, Vereda Llanogrande, Rionegro 054048, Colombia.
Nutrients. 2024 Jan 26;16(3):365. doi: 10.3390/nu16030365.
In a study addressing the high risk of chronic diseases in people with diabetes and obesity linked to metabolic syndrome, the impact of a Golden Berry diet was investigated using a diabetic animal model. Obese rats with diabetic characteristics were fed a diet containing five percent Golden Berry for 16 days. This study focused on various parameters including organ weights, expression of metabolic genes, and urinary biomarkers. Post-Golden Berry intake, there was a notable decrease in the body, liver, pancreas, visceral, and subcutaneous adipose tissue weights in these obese, hyperglycemic rats. In contrast, an increase in brown adipose tissue (BAT) cell mass was observed. This diet also resulted in reduced blood glucose levels and normalized plasma biochemical profiles, including cholesterol, triglycerides, LDL, and HDL levels. Additionally, it modulated specific urinary biomarkers, particularly pipe-colic acid, a primary marker for type 2 diabetes. Bioinformatics analysis linked these dietary effects to improved insulin signaling and adipogenesis. Regular consumption of Golden Berry effectively prevented insulin resistance and obesity in rats, underscoring its significant health benefits and the protective role of an antioxidant-rich diet against metabolic syndrome. These findings offer promising insights for future therapeutic strategies to manage and prevent obesity and related chronic diseases.
在一项针对与代谢综合征相关的糖尿病和肥胖人群的慢性疾病高风险的研究中，使用糖尿病动物模型研究了沙棘果饮食的影响。患有糖尿病特征的肥胖大鼠喂食含有 5%沙棘果的饮食 16 天。本研究重点关注了各种参数，包括器官重量、代谢基因的表达和尿生物标志物。摄入沙棘果后，这些肥胖、高血糖的大鼠的体重、肝脏、胰腺、内脏和皮下脂肪组织重量明显减少，而棕色脂肪组织 (BAT) 细胞质量增加。这种饮食还导致血糖水平降低，血浆生化谱正常化，包括胆固醇、甘油三酯、LDL 和 HDL 水平。此外，它还调节了特定的尿生物标志物，特别是哌可酸，这是 2 型糖尿病的主要标志物。生物信息学分析将这些饮食效应与改善胰岛素信号和脂肪生成联系起来。沙棘果的定期摄入可有效预防大鼠的胰岛素抵抗和肥胖，突出了其对健康的显著益处和富含抗氧化剂的饮食对代谢综合征的保护作用。这些发现为未来治疗策略提供了有希望的见解，以管理和预防肥胖症和相关的慢性疾病。
