Penisimplicins A 和 B：真菌 JXCC5 产生的新型聚酮肽杂合生物碱。
Penisimplicins A and B: Novel Polyketide-Peptide Hybrid Alkaloids from the Fungus JXCC5.
机构信息
School of Chemistry and Materials Science, South-Central Minzu University, Wuhan 430074, China.
School of Pharmaceutical Sciences, South-Central Minzu University, Wuhan 430074, China.
出版信息
Molecules. 2024 Jan 27;29(3):613. doi: 10.3390/molecules29030613.
In this study, two previously undescribed nitrogen-containing compounds, penisimplicins A () and B (), were isolated from JXCC5. The structures of and were elucidated on the basis of comprehensive spectroscopic data analysis, including 1D and 2D NMR and HRESIMS data. The absolute configuration of was determined by Marfey's method, ECD calculation, and DP4+ analysis. Both structures of and feature an unprecedented manner of amino acid-derivatives attaching to a polyketide moiety by C-C bond. The postulated biosynthetic pathways for and were discussed. Additionally, compound 1 exhibited significant acetylcholinesterase inhibitory activity, with IC values of 6.35 μM.
在这项研究中，从 JXCC5 中分离得到了两种以前未描述的含氮化合物，penisimplicins A()和 B()。和的结构是基于综合光谱数据分析确定的，包括 1D 和 2D NMR 和 HRESIMS 数据。的绝对构型是通过 Marfey 法、ECD 计算和 DP4+分析确定的。和的结构都采用了前所未有的方式，通过 C-C 键将氨基酸衍生物连接到聚酮部分上。讨论了和的假定生物合成途径。此外，化合物 1 表现出显著的乙酰胆碱酯酶抑制活性，IC 值为 6.35 μM。
Zotero 插件