Cea-Pavez Inés, Manteca-Bautista David, Morillo-Gomar Alejandro, Quirantes-Piné Rosa, Quiles José L
Research and Development Functional Food Centre (CIDAF), Health Science Technological Park, Avenida del Conocimiento 37, 18016 Granada, Spain.
Faculty of Pharmacy, University of Granada, Cartuja Campus, 18071 Granada, Spain.
Foods. 2024 Jan 28;13(3):425. doi: 10.3390/foods13030425.
The aim of this work is to develop different encapsulated propolis ingredients by spray-drying and to evaluate their bioaccessibility using simulated digestion. To achieve these goals, first, microparticles of a propolis extract with inulin as the coating polymer were prepared under the optimal conditions previously determined. Then, a fraction of inulin was replaced with other encapsulating agents, namely sodium alginate, pectin, and chitosan, to obtain different ingredients with controlled release properties in the gastrointestinal tract. The analysis of the phenolic profile in the propolis extract and microparticles showed 58 compounds tentatively identified, belonging mainly to phenolic acid derivatives and flavonoids. Then, the behavior of the free extract and the formulated microparticles under gastrointestinal conditions was studied through an gastrointestinal digestion process using the INFOGEST protocol. Digestion of the free extract resulted in the degradation of most compounds, which was minimized in the encapsulated formulations. Thus, all developed microparticles could be promising strategies for improving the stability of this bioactive extract under gastrointestinal conditions, thereby enhancing its beneficial effect.
这项工作的目的是通过喷雾干燥开发不同的包封蜂胶成分，并使用模拟消化评估其生物可及性。为实现这些目标，首先，在先前确定的最佳条件下制备了以菊粉为包衣聚合物的蜂胶提取物微粒。然后，用其他包封剂（即海藻酸钠、果胶和壳聚糖）替代一部分菊粉，以获得在胃肠道中具有控释特性的不同成分。对蜂胶提取物和微粒中酚类成分的分析表明，初步鉴定出58种化合物，主要属于酚酸衍生物和黄酮类化合物。然后，通过使用INFOGEST方案的胃肠消化过程，研究了游离提取物和制成的微粒在胃肠道条件下的行为。游离提取物的消化导致大多数化合物降解，而在包封制剂中这种降解最小化。因此，所有开发的微粒都可能是提高这种生物活性提取物在胃肠道条件下稳定性的有前景的策略，从而增强其有益效果。
