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柑橘生理性早期落果的非靶向代谢组学分析及抗脂作用

Untargeted Metabolomic Analyses and Antilipidemic Effects of Citrus Physiological Premature Fruit Drop.

机构信息

Longping Branch, College of Biology, Hunan University, Changsha 410125, China.

Hunan Agriculture Product Processing Institute, Dongting Laboratory, Hunan Provincial Key Laboratory of Fruits & Vegetables Storage, Processing, Quality and Safety, Hunan Academy of Agricultural Sciences, Changsha 410125, China.

出版信息

Int J Mol Sci. 2024 Feb 4;25(3):1876. doi: 10.3390/ijms25031876.

DOI:10.3390/ijms25031876
PMID:38339154
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10855584/
Abstract

Increasingly globally prevalent obesity and related metabolic disorders have underscored the demand for safe and natural therapeutic approaches, given the limitations of weight loss drugs and surgeries. This study compared the phytochemical composition and antioxidant activity of five different varieties of citrus physiological premature fruit drop (CPFD). Untargeted metabolomics was employed to identify variations in metabolites among different CPFDs, and their antilipidemic effects in vitro were assessed. The results showed that L. '' physiological premature fruit drop (DDPD) and '' physiological premature fruit drop (HYPD) exhibited higher levels of phytochemicals and stronger antioxidant activity. There were 97 differential metabolites identified in DDPD and HYPD, including phenylpropanoids, flavonoids, alkaloids, organic acids, terpenes, and lipids. Additionally, DDPD and HYPD demonstrated potential antilipidemic effects against oleic acid (OA)-induced steatosis in HepG2 hepatocytes and 3T3-L1 adipocytes. In conclusion, our findings reveal the outstanding antioxidant activity and antilipidemic effects of CPFD, indicating its potential use as a natural antioxidant and health supplement and promoting the high-value utilization of this resource.

摘要

由于减肥药物和手术的局限性，日益在全球流行的肥胖症和相关代谢紊乱凸显了对安全和天然治疗方法的需求。本研究比较了五种不同品种的柑橘生理落果（CPFD）的植物化学成分和抗氧化活性。采用无靶向代谢组学方法来鉴定不同 CPFD 之间代谢物的变化，并评估其体外抗脂作用。结果表明， '' 生理落果（DDPD）和 '' 生理落果（HYPD）表现出更高水平的植物化学成分和更强的抗氧化活性。在 DDPD 和 HYPD 中鉴定出 97 种差异代谢物，包括苯丙烷类、类黄酮、生物碱、有机酸、萜类化合物和脂质。此外，DDPD 和 HYPD 对 HepG2 肝细胞和 3T3-L1 脂肪细胞中油酸（OA）诱导的脂肪变性具有潜在的抗脂作用。总之，我们的研究结果揭示了 CPFD 出色的抗氧化活性和抗脂作用，表明其可能作为天然抗氧化剂和保健品使用，并促进了这一资源的高值化利用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6482/10855584/ec03f3b026f1/ijms-25-01876-g006.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6482/10855584/ec03f3b026f1/ijms-25-01876-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6482/10855584/00bb2d53ea4d/ijms-25-01876-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6482/10855584/fef99cec69dc/ijms-25-01876-g002.jpg
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