新型冠状病毒肺炎感染后急性后遗症患者外周血单个核细胞线粒体呼吸的改变
Altered mitochondrial respiration in peripheral blood mononuclear cells of post-acute sequelae of SARS-CoV-2 infection.
作者信息
Dirajlal-Fargo Sahera, Maison David P, Durieux Jared C, Andrukhiv Anastasia, Funderburg Nicholas, Ailstock Kate, Gerschenson Mariana, Mccomsey Grace A
机构信息
Case Western Reserve University, Cleveland, OH, USA; Ann and Robert Lurie Children's Hospital, Chicago, IL, USA.
Department of Cell and Molecular Biology, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, HI, USA.
出版信息
Mitochondrion. 2024 Mar;75:101849. doi: 10.1016/j.mito.2024.101849. Epub 2024 Feb 9.
Peripheral blood mononuclear cells (PBMC) mitochondrial respiration was measured ex vivo from participants without a history of COVID (n = 19), with a history of COVID and full recovery (n = 20), and with PASC (n = 20). Mean mitochondrial basal respiration, ATP-linked respiration, maximal respiration, spare respiration capacity, ATP-linked respiration, and non-mitochondrial respiration were highest in COVID + PASC+ (p ≤ 0.04). Every unit increase in non-mitochondrial respiration, ATP-linked respiration, basal respiration, spare respiration capacity, and maximal respiration increased the predicted odds of PASC between 1 % and 6 %. Mitochondrial dysfunction in PBMCs may be contributing to the etiology of PASC.
对没有新冠病史的参与者（n = 19）、有新冠病史且已完全康复的参与者（n = 20）以及患有新冠后综合征（PASC）的参与者（n = 20）的外周血单个核细胞（PBMC）进行离体线粒体呼吸测量。新冠+PASC+组的线粒体基础呼吸、ATP偶联呼吸、最大呼吸、备用呼吸能力、ATP偶联呼吸和非线粒体呼吸均值最高（p≤0.04）。非线粒体呼吸、ATP偶联呼吸、基础呼吸、备用呼吸能力和最大呼吸每增加一个单位，PASC的预测几率就增加1%至6%。PBMC中的线粒体功能障碍可能与PASC的病因有关。
Zotero 插件