Bi Xuewei, Liu Bo, Mao Zhinan, Wang Cunyang, Dunne Nicholas, Fan Yubo, Li Xiaoming
Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, School of Biological Science and Medical Engineering, Beihang University, Beijing 100083, China; Beijing Advanced Innovation Center for Biomedical Engineering, Beihang University, Beijing 100083, China.
International Research Center for Advanced Structural and Biomaterials, School of Materials Science & Engineering, Beihang University, Beijing 100191, China.
Mater Sci Eng C Mater Biol Appl. 2020 Dec;117:111326. doi: 10.1016/j.msec.2020.111326. Epub 2020 Aug 5.
The dura mater provides a barrier to protect the tissue underneath and cerebrospinal fluid. However, dural defects normally cause cerebrospinal fluid leakage and other complications, such as wound infections, meningitis, etc. Therefore, the reconstruction of dura mater has important clinical significance. Current dural reconstruction materials include: homologous, acellular, natural, synthetic, and composite materials. This review comprehensively summarizes the characteristics and efficacy of these dural substitutes, especially in clinical applications, including the advantages and drawbacks of those from different sources, the host tissue response in pre-clinical studies and clinical practice, and the comparison of these materials across different surgical procedures. Furthermore, the selections of materials for different surgical procedures are highlighted. Finally, the challenges and future perspectives in the development of ideal dural repair materials are discussed.
硬脑膜为其下方的组织和脑脊液提供了一道屏障。然而，硬脑膜缺损通常会导致脑脊液漏及其他并发症，如伤口感染、脑膜炎等。因此，硬脑膜重建具有重要的临床意义。目前的硬脑膜重建材料包括：同种异体材料、脱细胞材料、天然材料、合成材料和复合材料。本综述全面总结了这些硬脑膜替代物的特性和功效，尤其是在临床应用方面，包括不同来源材料的优缺点、临床前研究和临床实践中的宿主组织反应，以及这些材料在不同手术过程中的比较。此外，还强调了不同手术过程中材料的选择。最后，讨论了理想硬脑膜修复材料开发中的挑战和未来前景。
