Alqahtani Yahya S, Mahmoud Ashraf M, El-Wekil Mohamed M, Ibrahim Hossieny
Department of Pharmaceutical Chemistry, College of Pharmacy, Najran University Najran Saudi Arabia.
Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Assiut University Assiut Egypt.
RSC Adv. 2024 Feb 12;14(8):5406-5416. doi: 10.1039/d3ra08098f. eCollection 2024 Feb 7.
In the present study, nanoceria-decorated MWCNTs (CeNPs@MWCNTs) were synthesized using a simple and inexpensive process. Molnupiravir (MPV) has gained considerable attention in recent years due to the infection of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Since some people infected with COVID-19 experience fever and headaches, paracetamol (PCM) has been prescribed to relieve these symptoms. Therefore, there is an urgent need to monitor and detect these drugs simultaneously in pharmaceutical and biological samples. In this regard, we developed a novel sensor based on nanoceria-loaded MWCNTs (CeNPs@MWCNTs) for simultaneous monitoring of MPV and PCM. The incorporation of CeNPs@MWCNTs electrocatalyst into a glassy carbon microsphere fluorolube oil paste electrode (GCMFE) creates more active sites, which increase the surface area, electrocatalytic ability, and electron transfer efficiency. Interestingly, CeNPs@MWCNTs modified GCMFE demonstrated excellent detection limits (6.0 nM, 8.6 nM), linear ranges (5.0-5120 nM, 8.0-4162 nM), and sensitivities (78.6, 94.3 μA μM cm) for simultaneous detection of MPV and PCM. The developed CeNPs@MWCNTs electrocatalyst modified GCMFE exhibited good repeatability, anti-interference capability, stability, and real-time analysis with good recovery results, which clearly indicates that it can be used for real-time industrial applications.
在本研究中，采用简单且低成本的工艺合成了纳米氧化铈修饰的多壁碳纳米管（CeNPs@MWCNTs）。由于严重急性呼吸综合征冠状病毒2（SARS-CoV-2）感染，莫努匹拉韦（MPV）近年来受到了广泛关注。由于一些感染新冠病毒病（COVID-19）的人会出现发热和头痛症状，已开具对乙酰氨基酚（PCM）来缓解这些症状。因此，迫切需要在药物和生物样品中同时监测和检测这些药物。在这方面，我们开发了一种基于负载纳米氧化铈的多壁碳纳米管（CeNPs@MWCNTs）的新型传感器，用于同时监测MPV和PCM。将CeNPs@MWCNTs电催化剂掺入玻璃碳微球氟油膏电极（GCMFE）中可产生更多活性位点，从而增加表面积、电催化能力和电子转移效率。有趣的是，CeNPs@MWCNTs修饰的GCMFE在同时检测MPV和PCM时表现出出色的检测限（6.0 nM，8.6 nM）、线性范围（5.0 - 5120 nM，8.0 - 4162 nM）和灵敏度（78.6，94.3 μA μM cm）。所开发的CeNPs@MWCNTs电催化剂修饰的GCMFE具有良好的重复性、抗干扰能力、稳定性以及实时分析能力，回收率良好，这清楚地表明它可用于实时工业应用。
