Song Hao, Liu Huifang, Wang Xiufeng, Yang Yuteng, Zhao Xiangkun, Jiang Wen G, Sui Laijian, Song Xicheng
The Second Medical College, Binzhou Medical University, Yantai, China.
Department of Otorhinolaryngology, Head and Neck Surgery, Yantai Yuhuangding Hospital, Qingdao University, Yantai, China.
Front Oncol. 2024 Jan 30;13:1323751. doi: 10.3389/fonc.2023.1323751. eCollection 2023.
Cancer, ranks as the secondary cause of death, is a group of diseases that are characterized by uncontrolled tumor growth and distant metastasis, leading to increased mortality year-on-year. To date, targeted therapy to intercept the aberrant proliferation and invasion is crucial for clinical anticancer treatment, however, mutant expression of target genes often leads to drug resistance. Therefore, it is essential to identify more molecules that can be targeted to facilitate combined therapy. Previous studies showed that death associated protein 3 (DAP3) exerts a pivotal role in regulating apoptosis signaling of tumors, meanwhile, aberrant DAP3 expression is associated with the tumorigenesis and disease progression of various cancers. This review provides an overview of the molecule structure of DAP3 and the discrepant roles played by DAP3 in various types of tumors. Considering the molecular mechanism of DAP3-regulated cancer development, new potential treatment strategies might be developed in the future.
癌症是导致死亡的第二大原因，是一组以肿瘤生长失控和远处转移为特征的疾病，导致死亡率逐年上升。迄今为止，针对异常增殖和侵袭的靶向治疗对于临床抗癌治疗至关重要，然而，靶基因的突变表达常常导致耐药性。因此，识别更多可靶向的分子以促进联合治疗至关重要。先前的研究表明，死亡相关蛋白3（DAP3）在调节肿瘤细胞凋亡信号中发挥关键作用，同时，DAP3表达异常与多种癌症的肿瘤发生和疾病进展相关。本文综述了DAP3的分子结构以及DAP3在各种类型肿瘤中发挥的不同作用。考虑到DAP3调节癌症发展的分子机制，未来可能会开发出新的潜在治疗策略。
