Biomaterials Group, Department of Basic Medical Sciences, Faculty of Medicine and Health Sciences, Ghent University, De Pintelaan 185 Bdg. B 4th Floor, 9000 Ghent, Belgium.
Biomaterials Group, Department of Basic Medical Sciences, Faculty of Medicine and Health Sciences, Ghent University, De Pintelaan 185 Bdg. B 4th Floor, 9000 Ghent, Belgium.
Dent Mater. 2017 Apr;33(4):e186-e203. doi: 10.1016/j.dental.2017.01.007. Epub 2017 Feb 10.
Glass ionomer cements (GICs) are a subject of research because of their inferior mechanical properties, despite their advantages such as fluoride release and direct bonding to bone and teeth. Recent research aims to improve the bioactivity of the GICs and thereby improve mechanical properties on the long term. In this study, two types of bioactive glasses (BAG) (45S5F and CF9) are combined with GICs to evaluate the physico-chemical properties and biocompatibility of the BAG-GIC combinations. The effect of the addition of Al to the BAG composition and the use of smaller BAG particles on the BAG-GIC properties was also investigated.
Conventional aluminosilicate glass (ASG) and (modified) BAG were synthesized by the melt method. BAG-GIC were investigated on setting time, compressive strength and bioactivity. Surface changes were evaluated by Fourier transform infrared (FT-IR), scanning electron microscopy (SEM), EDS and PO -and Ca uptake in SBF. Biocompatibility of selected BAG-GICs was determined by a direct toxicity assay.
The addition of BAG improves the bioactivity of the GIC, which can be observed by the formation of an apatite (Ap) layer, especially in CF9-containing GICs. More BAG leads to more bioactivity but decreases strength. The addition of Al to the BAG composition improves strength, but decreases bioactivity. BAGs with smaller particle sizes have no effect on bioactivity and decrease strength. The formation of an Ap layer seems beneficial to the biocompatibility of the BAG-GICs.
Bioactive GICs may have several advantages over conventional GICs, such as remineralization of demineralized tissue, adhesion and proliferation of bone- and dental cells, allowing integration in surrounding tissue. CF9 BAG-GIC combinations containing maximum 10mol% Al are most promising, when added in ≤20wt% to a GIC.
尽管玻璃离子水门汀（GIC）具有释放氟化物和直接与骨和牙齿结合的优点，但由于其机械性能较差，因此仍是研究的课题。最近的研究旨在提高 GIC 的生物活性，从而长期改善其机械性能。在这项研究中，将两种类型的生物活性玻璃（BAG）（45S5F 和 CF9）与 GIC 结合在一起，以评估 BAG-GIC 组合的物理化学性质和生物相容性。还研究了向 BAG 成分中添加 Al 以及使用较小的 BAG 颗粒对 BAG-GIC 性能的影响。
通过熔融法合成传统的铝硅酸盐玻璃（ASG）和（改性）BAG。通过凝固时间、抗压强度和生物活性研究了 BAG-GIC。通过傅里叶变换红外（FT-IR）、扫描电子显微镜（SEM）、EDS 和 SBF 中 PO 和 Ca 的摄取来评估表面变化。通过直接毒性测定法确定选定的 BAG-GIC 的生物相容性。
BAG 的添加可提高 GIC 的生物活性，这可以通过形成磷灰石（Ap）层来观察到，特别是在含有 CF9 的 GIC 中。更多的 BAG 会导致更高的生物活性，但会降低强度。向 BAG 成分中添加 Al 可提高强度，但降低生物活性。粒径较小的 BAG 对生物活性没有影响，但会降低强度。形成 Ap 层似乎有利于 BAG-GIC 的生物相容性。
生物活性 GIC 可能比传统 GIC 具有多个优势，例如脱矿组织的再矿化、骨和牙齿细胞的黏附和增殖，从而允许与周围组织整合。当以≤20wt%添加到 GIC 中时，含有最大 10mol%Al 的 CF9 BAG-GIC 组合最有前途。
