Rajendrasozhan Saravanan
Department of Chemistry, College of Sciences, University of Ha'il, Ha'il 55473, Saudi Arabia.
Bioinformation. 2024 Jan 31;20(1):11-17. doi: 10.6026/973206300200011. eCollection 2024.
Garlic and ginger are well known as safe alternatives to traditional therapies. Limited information exists regarding antioxidant, antibacterial and antiviral capabilities of the combination of ginger and garlic. Standard methodologies were employed to determine the phytochemical compositions. Antioxidant activities were evaluated through DPPH and FRAP assays. Notably, in DPPH assay, combination of ginger and garlic extracts displayed significantly higher (85.44%, p < 0.005) antioxidant activity even at lower concentrations (6 mg/ml) compared to ginger and garlic extracts alone. Similar findings were observed for FRAP assay. At low concentration of extracts (25 µg/ml), combination of ginger and garlic exhibited significant (p < 0.005) increase in reducing activity (51%) compared to ginger or garlic extracts alone. Significant antibacterial and antiviral activities were exhibited by the combination of both ginger and garlic extracts as compared to ginger and garlic extracts alone. The combined effect of garlic and ginger exhibited a synergistic effect in bacterial and viral growth inhibition. These findings suggest that the diverse phytochemical compositions of the ginger and garlic varieties contribute to their strong antioxidant properties, potentially positioning them as valuable therapeutics for bacterial and viral infections. Further analysis will be required for their widespread utilization and pharmaceutical applications.
大蒜和生姜作为传统疗法的安全替代物而广为人知。关于生姜和大蒜组合的抗氧化、抗菌和抗病毒能力的信息有限。采用标准方法来确定植物化学成分。通过DPPH和FRAP测定法评估抗氧化活性。值得注意的是,在DPPH测定中,即使在较低浓度(6毫克/毫升)下,生姜和大蒜提取物的组合与单独的生姜和大蒜提取物相比,也表现出显著更高(85.44%,p < 0.005)的抗氧化活性。FRAP测定也观察到类似结果。在提取物低浓度(25微克/毫升)时,生姜和大蒜的组合与单独的生姜或大蒜提取物相比,还原活性显著增加(51%,p < 0.005)。与单独的生姜和大蒜提取物相比,生姜和大蒜提取物的组合表现出显著的抗菌和抗病毒活性。大蒜和生姜的联合作用在抑制细菌和病毒生长方面表现出协同效应。这些发现表明,生姜和大蒜品种多样的植物化学成分促成了它们强大的抗氧化特性,这可能使它们成为治疗细菌和病毒感染的有价值的治疗剂。要实现它们的广泛应用和药物应用,还需要进一步分析。