Department of Genetics and Biotechnology, St. Petersburg State University, St. Petersburg, Russian Federation.
Curr Genet. 2024 Feb 14;70(1):1. doi: 10.1007/s00294-024-01280-y.
GATA family transcription factors (GATA-TFs) are metalloproteins that regulate many metabolic pathways. These conserved proteins recognize the consensus sequence (A/T)GATA(A/G) in the promoter regions of many genes and regulate their transcription in response to environmental signals. Currently, the study of GATA-TFs is of increasing interest. GATA genes and their proteins are most actively studied in vascular plants and fungi. Based on the results of numerous studies, it has been shown that GATA factors regulate the metabolic pathways of nitrogen and carbon, and also play a major role in the processes induced by light and circadian rhythms. In algae, GATA-TFs remain poorly studied, and information about them is scattered. In this work, all known data on GATA-TFs in the unicellular green alga Chlamydomonas reinhardtii has been collected and systematized. The genome of this alga contains 12 GATA coding genes. Using the phylogenetic analysis, we identified three classes of GATA factors in C. reinhardtii according to the structure of the zinc finger domain and showed their difference from the classification of GATA factors developed on vascular plants.
GATA 家族转录因子（GATA-TFs）是一类金属蛋白酶，可调控多种代谢途径。这些保守蛋白可识别许多基因启动子区域的共有序列（A/T）GATA（A/G），并根据环境信号调控其转录。目前，GATA-TFs 的研究兴趣日益浓厚。GATA 基因及其蛋白在维管植物和真菌中研究得最为深入。基于大量研究结果，已表明 GATA 因子调控氮和碳的代谢途径，并且在光诱导和昼夜节律过程中也发挥主要作用。在藻类中，GATA-TFs 的研究仍不够充分，有关它们的信息较为分散。在这项工作中，收集并系统整理了单细胞绿藻莱茵衣藻中所有已知的 GATA-TFs 数据。该藻类的基因组包含 12 个 GATA 编码基因。通过系统发生分析，根据锌指结构域的结构，我们在 C. reinhardtii 中鉴定出了三类 GATA 因子，并展示了它们与在维管植物中建立的 GATA 因子分类的区别。
