Babajide Oladapo, Kjaergaard Alisa D, Deng Weichen, Kuś Aleksander, Sterenborg Rosalie B T M, Åsvold Bjørn Olav, Burgess Stephen, Teumer Alexander, Medici Marco, Ellervik Christina, Nick Bass, Deloukas Panos, Marouli Eirini
Queen Mary University of London, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, London, UK.
Aarhus University Hospital, Steno Diabetes Center, Hedeager Aarhus, Denmark.
Borderline Personal Disord Emot Dysregul. 2024 Feb 15;11(1):2. doi: 10.1186/s40479-024-00246-3.
Genome-wide association studies have reported a genetic overlap between borderline personality disorder (BPD) and schizophrenia (SCZ). Epidemiologically, the direction and causality of the association between thyroid function and risk of BPD and SCZ are unclear. We aim to test whether genetically predicted variations in TSH and FT4 levels or hypothyroidism are associated with the risk of BPD and SCZ.
We employed Mendelian Randomisation (MR) analyses using genetic instruments associated with TSH and FT4 levels as well as hypothyroidism to examine the effects of genetically predicted thyroid function on BPD and SCZ risk. Bidirectional MR analyses were employed to investigate a potential reverse causal association.
Genetically predicted higher FT4 was not associated with the risk of BPD (OR: 1.18; P = 0.60, IVW) or the risk of SCZ (OR: 0.93; P = 0.19, IVW). Genetically predicted higher TSH was not associated with the risk of BPD (OR: 1.11; P = 0.51, IVW) or SCZ (OR: 0.98, P = 0.55, IVW). Genetically predicted hypothyroidism was not associated with BPD or SCZ. We found no evidence for a reverse causal effect between BPD or SCZ on thyroid function.
We report evidence for a null association between genetically predicted FT4, TSH or hypothyroidism with BPD or SCZ risk. There was no evidence for reverse causality.
全基因组关联研究报告了边缘性人格障碍（BPD）与精神分裂症（SCZ）之间存在遗传重叠。在流行病学上，甲状腺功能与BPD和SCZ风险之间关联的方向和因果关系尚不清楚。我们旨在测试遗传预测的促甲状腺激素（TSH）和游离甲状腺素（FT4）水平变化或甲状腺功能减退是否与BPD和SCZ风险相关。
我们采用孟德尔随机化（MR）分析，使用与TSH和FT4水平以及甲状腺功能减退相关的遗传工具，来检验遗传预测的甲状腺功能对BPD和SCZ风险的影响。采用双向MR分析来研究潜在的反向因果关联。
遗传预测的较高FT4水平与BPD风险（比值比：1.18；P = 0.60，逆方差加权法）或SCZ风险（比值比：0.93；P = 0.19，逆方差加权法）无关。遗传预测的较高TSH水平与BPD风险（比值比：1.11；P = 0.51，逆方差加权法）或SCZ风险（比值比：0.98，P = 0.55，逆方差加权法）无关。遗传预测的甲状腺功能减退与BPD或SCZ无关。我们没有发现BPD或SCZ对甲状腺功能有反向因果效应的证据。
我们报告了遗传预测的FT4、TSH或甲状腺功能减退与BPD或SCZ风险之间无关联的证据。没有反向因果关系的证据。
