Wahyuni Ika, Aulifa Diah Lia, Rosdianto Aziiz Mardanarian, Levita Jutti
Master Program in Pharmacy, Faculty of Pharmacy, Universitas Padjadjaran, Sumedang, 45363, West Java, Indonesia.
Faculty of Health, Universitas Nahdlatul Ulama, Mataram, West Nusa Tenggara, Indonesia.
Heliyon. 2024 Jan 13;10(2):e24119. doi: 10.1016/j.heliyon.2024.e24119. eCollection 2024 Jan 30.
Chronic exposure to elevated levels of pro-oxidant factors may cause structural failings at the mitochondrial DNA level and alteration of antioxidant enzymes (glutathione peroxidase, catalase, and superoxide dismutase). Oxidative stress is an imbalance between the capacity of endogenous non-enzymatic antioxidants (glutathione, alpha-lipoic acid, uric acid, ferritin, metallothionein, melatonin, and bilirubin) and the occurrence of pro-oxidant factors which may lead to the pathogenesis of various diseases that affects the kidneys, pancreas, central nervous system, and cardiovascular system. Therefore, the utilization of medicinal plants with antioxidant activity, e.g., Koidzumi which contains chalcones, is interesting to be explored. Chalcones exhibit direct and indirect antioxidant activity and prevent oxidative stress by decreasing ROS, RNS, and superoxide production. In this review, we discuss the pharmacology activities of Koidzumi and its efficacy in humans. The articles were explored on PubMed and Google Scholar databases and based on the titles and abstracts related to the topic of interest, and 55 articles were selected. Two main chalcones of this plant, 4-hydroxyderricin and xanthoangelol, have been reported for their various pharmacology activities. The efficacy of was confirmed in anti-obesity, hepatoprotective, anti-diabetes mellitus, and increasing plasma antioxidants in patients with metabolic syndrome. is safe as proven by only mild or no adverse events reported, thus it is prospective to be further developed as an antioxidant nutraceutical.
长期暴露于高水平的促氧化因子可能会导致线粒体DNA水平的结构缺陷以及抗氧化酶（谷胱甘肽过氧化物酶、过氧化氢酶和超氧化物歧化酶）的改变。氧化应激是内源性非酶抗氧化剂（谷胱甘肽、α-硫辛酸、尿酸、铁蛋白、金属硫蛋白、褪黑素和胆红素）的能力与促氧化因子的产生之间的失衡，这可能导致影响肾脏、胰腺、中枢神经系统和心血管系统的各种疾病的发病机制。因此，探索具有抗氧化活性的药用植物，例如含有查耳酮的小泉紫珠，是很有意义的。查耳酮具有直接和间接的抗氧化活性，并通过减少活性氧、活性氮和超氧化物的产生来预防氧化应激。在这篇综述中，我们讨论了小泉紫珠的药理活性及其对人类的功效。我们在PubMed和谷歌学术数据库上搜索了相关文章，并根据与感兴趣主题相关的标题和摘要，筛选出了55篇文章。该植物的两种主要查耳酮，4-羟基德里辛和黄当归醇，已被报道具有多种药理活性。在抗肥胖、保肝、抗糖尿病以及提高代谢综合征患者血浆抗氧化剂水平方面，其功效得到了证实。小泉紫珠被证实是安全的，仅报告了轻微或无不良事件，因此它有望进一步开发成为一种抗氧化营养保健品。
