西澳地区子痫前期对五岁儿童社会和情感发育脆弱性的影响：一项基于人群数据的关联研究。

The effects of pre-eclampsia on social and emotional developmental vulnerability in children at age five in Western Australia: A population data linkage study.

机构信息

Australian Centre for Precision Health, UniSA Clinical & Health Sciences, University of South Australia, Adelaide, SA 5000, Australia; Curtin School of Population Health, Curtin University, Kent St, Bentley, WA 6102, Australia; South Australian Health and Medical Research Institute, Adelaide, SA 5000, Australia.

Curtin School of Population Health, Curtin University, Kent St, Bentley, WA 6102, Australia.

出版信息

J Affect Disord. 2024 May 1;352:349-356. doi: 10.1016/j.jad.2024.02.042. Epub 2024 Feb 13.

DOI:10.1016/j.jad.2024.02.042

PMID:38360367

Abstract

BACKGROUND

It is important to explore factors that may hinder early childhood development in AEDC Emotional Maturity and Social Competence domains as these underpin the foundation for health, well-being, and productivity over the life course. No previous study has examined whether, or to what extent, preeclampsia increases the risk of developmental vulnerability in social and emotional domains in early childhood.

METHODS

We conducted a retrospective population-based cohort study on the association between preeclampsia and childhood developmental vulnerability in emotional maturity and social competence domains in children born in Western Australia in 2009, 2012 and 2015. We obtained records of births, developmental anomalies, midwives notifications and hospitalisations. These data were linked to the Australian Early Development Census (AEDC), from which developmental vulnerability in emotional maturity and social competence domains at a median age of 5 years was ascertained. Causal relative risks (RR) were estimated with doubly robust estimation.

RESULTS

A total of 64,391 mother-offspring pairs were included in the final analysis. For the whole cohort, approximately 25 % and 23 % of children were classified as developmentally vulnerable or at-risk on AEDC emotional maturity and social competence domains, respectively. Approximately 2.8 % of children were exposed in utero to preeclampsia. Children exposed to preeclampsia were more likely to be classified as developmentally vulnerable or at-risk on the emotional maturity (RR = 1.19, 95%CI:1.11-1.28) and social competence domains (RR = 1.22, 95 % CI:1.13-1.31).

CONCLUSION

Children exposed to pre-eclampsia in utero were more likely to be developmentally vulnerable in emotional maturity and social competence domains in this cohort. Our findings provide new insights into the harmful effect of preeclampsia on childhood developmental vulnerability.

摘要

背景

探索可能阻碍 AEDC 情绪成熟度和社会竞争力领域儿童早期发展的因素很重要，因为这些因素是健康、幸福和整个生命周期生产力的基础。以前没有研究检验过子痫前期是否会增加儿童在社会和情感领域发展脆弱的风险，以及增加的程度如何。

方法

我们对 2009 年、2012 年和 2015 年在西澳大利亚出生的儿童进行了一项回顾性基于人群的队列研究，以探讨子痫前期与儿童在情绪成熟度和社会竞争力领域发展脆弱性之间的关系。我们获得了出生记录、发育异常、助产士通知和住院记录。这些数据与澳大利亚早期发展普查（AEDC）相关联，从中确定了 5 岁时情绪成熟度和社会竞争力领域发展脆弱性的儿童。使用双重稳健估计来估计因果相对风险（RR）。

结果

共有 64391 对母婴对纳入最终分析。对于整个队列，大约 25%和 23%的儿童在 AEDC 情绪成熟度和社会竞争力领域被归类为发育脆弱或有风险，分别。大约 2.8%的儿童在子宫内暴露于子痫前期。暴露于子痫前期的儿童在情绪成熟度（RR=1.19，95%CI：1.11-1.28）和社会竞争力领域（RR=1.22，95%CI：1.13-1.31）被归类为发育脆弱或有风险的可能性更高。