Department of Physics and Astronomy, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
Department of Applied Physical Sciences, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
Sci Rep. 2024 Feb 16;14(1):3887. doi: 10.1038/s41598-024-54529-4.
Multisource cone beam computed tomography CBCT (ms-CBCT) has been shown to overcome some of the inherent limitations of a conventional CBCT. The purpose of this study was to evaluate the accuracy of ms-CBCT for measuring the bone mineral density (BMD) of mandible and maxilla compared to the conventional CBCT. The values measured from a multi-detector CT (MDCT) were used as substitutes for the ground truth. An anthropomorphic adult skull and tissue equivalent head phantom and a homemade calibration phantom containing inserts with varying densities of calcium hydroxyapatite were imaged using the ms-CBCT, the ms-CBCT operating in the conventional single source CBCT mode, and two clinical CBCT scanners at similar imaging doses; and a clinical MDCT. The images of the anthropomorphic head phantom were reconstructed and registered, and the cortical and cancellous bones of the mandible and the maxilla were segmented. The measured CT Hounsfield Unit (HU) and Greyscale Value (GV) at multiple region-of-interests were converted to the BMD using scanner-specific calibration functions. The results from the various CBCT scanners were compared to that from the MDCT. Statistical analysis showed a significant improvement in the agreement between the ms-CBCT and MDCT compared to that between the CBCT and MDCT.
多源锥形束 CT（ms-CBCT）已被证明可以克服传统 CBCT 的一些固有局限性。本研究旨在评估 ms-CBCT 测量下颌骨和上颌骨骨矿物质密度（BMD）的准确性，与传统 CBCT 相比。多探测器 CT（MDCT）测量的值被用作真实值的替代值。使用 ms-CBCT、以传统单源 CBCT 模式运行的 ms-CBCT 以及两种类似成像剂量的临床 CBCT 扫描仪对具有不同羟磷灰石密度的插入物的定制校准体模和拟人化成人颅骨和组织等效头部体模进行成像；和临床 MDCT。对拟人头部体模的图像进行重建和配准，并对下颌骨和上颌骨的皮质骨和松质骨进行分割。使用特定于扫描仪的校准函数，将多个感兴趣区域的测量 CT 亨氏单位（HU）和灰度值（GV）转换为 BMD。将来自各种 CBCT 扫描仪的结果与来自 MDCT 的结果进行比较。统计分析表明，与 CBCT 相比，ms-CBCT 与 MDCT 的一致性有了显著提高。
