Liu Xinying, Yuen Michael, Yuen Tina, Yuen Hywel, Wang Min, Peng Qiang
College of Food Science and Engineering Northwest A&F University Yangling China.
Puredia Limited Xining China.
Food Sci Nutr. 2023 Dec 7;12(2):1082-1094. doi: 10.1002/fsn3.3823. eCollection 2024 Feb.
Oxidative stress in skin cells caused by changes in the external environment is one of the principal causes of skin aging. Sea buckthorn proanthocyanidins (SBPs) have good free radical scavenging ability. We established a senescence model by injecting 500 mg/kg D-galactose into the dorsal necks of mice, and then different doses of SBP (25, 50, and 100 mg/kg) were gavaged to explore the effects of SBP on the skin tissues of senescent mice and elucidate the related mechanism of action. The results reveal that SBP can alleviate the skin aging phenomenon caused by D-galactose-induced aging. It can also enhance the total antioxidant capacity in the body, thereby strengthening the body's antioxidant defense capability. In addition, SBP can effectively improve skin aging by regulating the TGF-β1/Smads pathway and MMPs/TIMP system, increasing the relative content of Col I and tropoelastin, further maintaining the stability of collagen fiber and elastic fiber structure. These results will provide the development and production of the antioxidant function of cosmetics and health products, providing a new train of thought.
外部环境变化引起的皮肤细胞氧化应激是皮肤衰老的主要原因之一。沙棘原花青素（SBPs）具有良好的自由基清除能力。我们通过向小鼠背部颈部注射500mg/kg D-半乳糖建立衰老模型，然后灌胃不同剂量的SBP（25、50和100mg/kg），以探究SBP对衰老小鼠皮肤组织的影响，并阐明其相关作用机制。结果表明，SBP可缓解D-半乳糖诱导的衰老引起的皮肤衰老现象。它还能提高体内的总抗氧化能力，从而增强机体的抗氧化防御能力。此外，SBP可通过调节TGF-β1/Smads信号通路和MMPs/TIMP系统，增加I型胶原蛋白和原弹性蛋白的相对含量，进一步维持胶原纤维和弹性纤维结构的稳定性，有效改善皮肤衰老。这些结果将为化妆品和保健品抗氧化功能的开发生产提供新思路。
