二甲基砜对 UVB 诱导皮肤损伤的影响：小鼠模型的实验研究。
Effects of Methylsulfonylmethane on UVB-induced Skin Damage: An Experimental Study in a Mouse Model.
机构信息
Department of Plastic and Reconstructive Surgery, School of Medicine, Kyungpook National University, Daegu, Republic of Korea.
Department of Plastic and Reconstructive Surgery, School of Medicine, Kyungpook National University, Daegu, Republic of Korea
出版信息
In Vivo. 2022 Nov-Dec;36(6):2714-2721. doi: 10.21873/invivo.13007.
BACKGROUND/AIM: The skin protects the body from ultraviolet rays and other external factors. Various studies have been conducted to identify methods to prevent skin aging and damage. To investigate the protective effects of methylsulfonylmethane (MSM), in this study, a hairless mouse model was used.
PATIENTS AND METHODS
Mice divided into Groups B, C, and D were subjected to UVB irradiation for six weeks, and Group A was considered the control. Retinoic acid is a substance that has been proven to have anti-aging properties. Group C was injected with MSM, group D was injected with retinoic acid, and groups A and B were injected with saline. At the end of the experiment, the degree of senescence was confirmed through visual evaluation, histopathological analysis, immunohistochemistry, and elasticity measurement using SEM.
RESULTS
After the end of the experiment, the wrinkle score was 0.4, 2.5, 1.8, 1.5 for Groups A, B, C, and D, respectively. Epidermal thickness was 40 μm, 70 μm, 60 μm, 55 μm in Groups A, B, C, and D, respectively. Group C showed less collagen confirmation loss and more angiogenesis and elastin precursor production. Elastic fiber linearity was 0.901±0.02, 0.551±0.04, 0.751±0.04, 0.822±0.03 for Groups A, B, C, and D, respectively.
CONCLUSION
Injection of MSM in mice subjected to UVB-induced skin damage reduces the wrinkle score and protects against photoaging.
背景/目的：皮肤可保护机体免受紫外线和其他外部因素的伤害。已有多项研究旨在寻找预防皮肤衰老和损伤的方法。本研究旨在探讨二甲亚砜（MSM）的保护作用，采用无毛小鼠模型进行研究。
患者与方法
将小鼠分为 B、C 和 D 组，接受 UVB 照射 6 周，A 组为对照组。维甲酸是一种已证实具有抗衰老作用的物质。C 组注射 MSM，D 组注射维甲酸，A、B 组注射生理盐水。实验结束时，通过肉眼评估、组织病理学分析、免疫组织化学和 SEM 弹性测量来确认衰老程度。
结果
实验结束时，A、B、C 和 D 组的皱纹评分为 0.4、2.5、1.8 和 1.5。A、B、C 和 D 组的表皮厚度分别为 40μm、70μm、60μm 和 55μm。C 组胶原蛋白丢失较少，血管生成和弹性蛋白前体生成较多。弹性纤维线性度分别为 0.901±0.02、0.551±0.04、0.751±0.04 和 0.822±0.03。
结论
MSM 注射可减轻 UVB 诱导的皮肤损伤小鼠的皱纹评分，预防光老化。
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