Cho Cheol Hyeon, Lim Wonchul, Sim Woo-Jin, Lim Tae-Gyu
Department of Food Science & Biotechnology, Sejong University, Seoul, 05006 Republic of Korea.
Department of Food Science & Biotechnology, and Carbohydrate Bioproduct Research Center, Sejong University, Seoul, 05006 Republic of Korea.
Food Sci Biotechnol. 2023 Jul 3;33(4):955-967. doi: 10.1007/s10068-023-01362-6. eCollection 2024 Mar.
Skin aging is induced by exposure to extrinsic factors, causing various diseases and adversely affecting aesthetics. Studies have suggested that as the quality of life improves, demand for beauty and nutritional cosmetics increases. Here, the protective effects of collagen peptide against UV-induced skin damage were evaluated in vitro and in vivo. Collagen peptide inhibited water loss and UVB irradiation-induced HA degradation in the skin of SKH-1 mice. Additionally, collagen peptide dose-dependently inhibited UVB-induced wrinkle formation, epidermal thickness, and elastase activity. These results suggest that collagen peptide regulates collagen degradation through the MAPK and MAPKK pathway. In addition, collagen peptide administration did not affect changes in weight of the liver, spleen, and kidney, or enzymatic indicators of liver damage. Taken together, oral administration of collagen peptide improved the effects of UV-induced skin aging without toxicity. Therefore, this study supports the development of collagen peptide for skin aging prevention in nutricosmetic products.
The online version contains supplementary material available at 10.1007/s10068-023-01362-6.
皮肤老化是由暴露于外在因素引起的，会导致各种疾病并对美观产生不利影响。研究表明，随着生活质量的提高，对美容和营养化妆品的需求增加。在此，在体外和体内评估了胶原蛋白肽对紫外线诱导的皮肤损伤的保护作用。胶原蛋白肽抑制了SKH-1小鼠皮肤中的水分流失和紫外线B照射诱导的透明质酸降解。此外，胶原蛋白肽剂量依赖性地抑制紫外线B诱导的皱纹形成、表皮厚度和弹性蛋白酶活性。这些结果表明，胶原蛋白肽通过丝裂原活化蛋白激酶（MAPK）和丝裂原活化蛋白激酶激酶（MAPKK）途径调节胶原蛋白降解。此外，给予胶原蛋白肽不影响肝脏、脾脏和肾脏的重量变化或肝损伤的酶指标。综上所述，口服胶原蛋白肽可改善紫外线诱导的皮肤老化效果且无毒性。因此，本研究支持在营养化妆品中开发用于预防皮肤老化的胶原蛋白肽。
在线版本包含可在10.1007/s10068-023-01362-6获取的补充材料。
