Liu Zhen-Hua, Ma Rui-Jing, Yang Liu, Li Jin-Yu, Hou Bo, Hu Jiang-Miao, Zhou Jun
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China; University of Chinese Academy of Sciences, Beijing 100049, People's Republic of China; Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China.
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China; Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China.
Fitoterapia. 2017 Jun;119:130-135. doi: 10.1016/j.fitote.2017.04.011. Epub 2017 Apr 26.
Three new triterpenoids, patrinolides B-D (1-3), and two new iridoids, patriscabioins K-L (9-10), together with five known compounds (4-8) were isolated from the extract of the whole plants of Patrinia scabiosaefolia. Compounds 1, 9, and 10 contained the unique substituents in Valerianaceae family, such as isovalery and 3-methylcrotonyl. Compound 2 was a 24-nor-ursane triterpenoid. Their structures were established on the basis of extensive spectroscopic analysis (UV, IR, MS, 1D and 2D NMR). The inhibitory activities against nitric oxide synthase (NOS) of all triterpenoids were tested. The results showed that compound 4 had moderate inhibitory activity with IC of 10.1μM. Furthermore, it also showed strongest inhibitory activities on AChE with IC values of 10.0μM.
从黄花败酱全草提取物中分离得到3个新的三萜类化合物，败酱内酯B-D（1-3），2个新的环烯醚萜类化合物，败酱草苷K-L（9-10），以及5个已知化合物（4-8）。化合物1、9和10含有缬草科特有的取代基，如异戊酰基和3-甲基巴豆酰基。化合物2是一种24-降乌苏烷型三萜类化合物。它们的结构是基于广泛的光谱分析（紫外、红外、质谱、一维和二维核磁共振）确定的。测试了所有三萜类化合物对一氧化氮合酶（NOS）的抑制活性。结果表明，化合物4具有中等抑制活性，IC50为10.1μM。此外，它对乙酰胆碱酯酶也表现出最强的抑制活性，IC50值为10.0μM。
