獐牙菜苦苷元类化合物从獐牙菜的根部分离及其对一氧化氮产生的抑制作用。
Non-glycosidic iridoids from the roots of Patrinia scabra and their nitric oxide production inhibitory effects.
机构信息
Department of Life and Nanopharmaceutical Sciences, Graduate School, Kyung Hee University, Seoul, 02447, Republic of Korea.
Department of Biosystems and Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul, 02841, Republic of Korea.
出版信息
Arch Pharm Res. 2019 Sep;42(9):766-772. doi: 10.1007/s12272-019-01117-0. Epub 2019 Feb 5.
Phytochemical investigation on the 70% aqueous EtOH extract from the roots of Patrinia scabra led to the isolation and characterization of five new non-glycosidic iridoids, patriscabrins F-J (1-5), along with a known iridoid 11-ethoxyviburtinal (6). The structures of the new compounds 1-5 were determined by interpretation of spectroscopic data, particularly by 1D- and 2D-NMR and ECD studies. Thereafter, the isolates 1-6 were evaluated for their inhibitory effects on lipopolysaccharide-induced nitric oxide production in RAW 264.7 cells. Of these, patriscabrin F (1) exhibited the most potent inhibitory effect with observed IC value of 14.1 μM. In addition, patriscabrin G (2) and 11-ethoxyviburtinal (6) showed IC values 24.6 and 35.5 μM, respectively.
从三叶鬼针草 Patrinia scabra 的 70%乙醇根提取物中进行植物化学研究，分离并鉴定了五个新的非糖苷类环烯醚萜，分别命名为 patriscabrins F-J（1-5），以及一个已知的环烯醚萜 11-乙氧基 Viburtinal（6）。通过对光谱数据的解析，特别是通过 1D 和 2D-NMR 和 ECD 研究，确定了这些新化合物 1-5 的结构。然后，对分离得到的化合物 1-6 进行了 LPS 诱导的 RAW 264.7 细胞中一氧化氮产生的抑制活性评价。结果显示，化合物 1 表现出最强的抑制活性，其 IC50 值为 14.1 μM。此外，化合物 2 和 6 的 IC50 值分别为 24.6 和 35.5 μM。
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