Medical and Biological Computing Laboratory, School of Biosciences and Technology (SBST), Vellore Institute of Technology (VIT), Vellore, Tamil Nadu, India.
Department of Bio-Sciences, SBST, VIT, Vellore, Tamil Nadu, India.
Rev Med Virol. 2024 Mar;34(2):e2524. doi: 10.1002/rmv.2524.
The Human Papillomavirus (HPV) infection is responsible for more than 80% of reported cervical cancer and other virus-associated tumours. Although this global threat can be controlled using effective vaccination strategies, a growing perturbation of HPV infection is an emerging coinfection likely to increase the severity of the infection in humans. Moreover, these coinfections prolong the HPV infections, thereby risking the chances for oncogenic progression. The present review consolidated the clinically significant microbial coinfections/co-presence associated with HPV and their underlying molecular mechanisms. We discussed the gaps and concerns associated with demography, present vaccination strategies, and other prophylactic limitations. We concluded our review by highlighting the potential clinical as well as emerging computational intervention measures to kerb down HPV-associated severities.
人乳头瘤病毒 (HPV) 感染是导致 80%以上报告的宫颈癌和其他病毒相关肿瘤的罪魁祸首。尽管可以通过有效的疫苗接种策略来控制这种全球威胁，但 HPV 感染的不断增加可能是一种新的混合感染，这可能会增加人类感染的严重程度。此外，这些混合感染会延长 HPV 感染时间，从而增加致癌进展的风险。本综述整合了与 HPV 相关的具有临床意义的微生物混合感染/共存及其潜在的分子机制。我们讨论了与人口统计学、当前疫苗接种策略和其他预防措施相关的差距和关注点。最后，我们通过强调潜在的临床和新兴的计算干预措施来控制 HPV 相关的严重程度，结束了我们的综述。
