Thakur Mamta, Vijayamohanan Lekshmi, Asotra Sarita
Department of Pathology, IGMC Shimla, Himachal Pradesh, India.
J Cancer Res Ther. 2023 Jan 1;19(Suppl 2):S770-S774. doi: 10.4103/jcrt.jcrt_174_22. Epub 2023 Sep 21.
Skin appendageal tumors (SAT) are a rare group of tumors that are classified according to their line of appendageal differentiation along eccrine, apocrine, follicular, and sebaceous lines. However, they are relatively uncommon and create diagnostic difficulties for the pathologist. Recognition of malignant transformation adds to the importance of an accurate diagnosis. A paucity of clinicopathological data from the Himalayan region of India, in particular, prompted the conduct of this study.
To study the clinical and histopathological spectrum of SAT during a period of 1 year received at our hospital.
A retrospective study was carried out at the Pathology department of our hospital. All relevant clinical characteristics were noted in addition to the histopathological features. Slides stained with both hematoxylin and eosin and special stains where necessary were used to supplement the diagnoses.
A total of 17 cases were diagnosed in 1 year (January 2021 to December 2021) at our institute. The predominant age group was 40-59 years. Females outnumbered males, with a male: female ratio of 0.8:1. The most common location of tumors was in the head and neck (90.90%). The majority of cases were benign (90.90%). The majority of tumors were of follicular differentiation (54.55%). We found one malignant tumor of sebaceous differentiation.
The clinical presentation is remarkably similar to most SAT. In our study, we found that majority of tumors were benign and located in the head and neck. The importance of an accurate histopathological diagnosis is essential in these tumors to diagnose the malignant counterparts and differentiate them from more common skin tumors with different prognoses.
皮肤附属器肿瘤(SAT)是一组罕见的肿瘤,根据其沿小汗腺、大汗腺、毛囊和皮脂腺谱系的附属器分化线进行分类。然而,它们相对不常见,给病理学家带来诊断困难。认识到恶性转化增加了准确诊断的重要性。特别是来自印度喜马拉雅地区的临床病理数据匮乏,促使开展了本研究。
研究我院1年内收治的SAT的临床和组织病理学特征。
在我院病理科进行回顾性研究。除组织病理学特征外,还记录了所有相关临床特征。必要时使用苏木精和伊红染色以及特殊染色的玻片来辅助诊断。
我院在1年(2021年1月至2021年12月)共诊断出17例。主要年龄组为40 - 59岁。女性多于男性,男女比例为0.8:1。肿瘤最常见的部位是头颈部(90.90%)。大多数病例为良性(90.90%)。大多数肿瘤为毛囊分化(54.55%)。我们发现了1例皮脂腺分化的恶性肿瘤。
临床表现与大多数SAT非常相似。在我们的研究中,我们发现大多数肿瘤为良性,且位于头颈部。准确的组织病理学诊断对于诊断这些肿瘤的恶性对应物并将它们与具有不同预后的更常见皮肤肿瘤区分开来至关重要。